BDBM50605550 C-188-9::Stat3 inhibitor c188-9::Stat3 inhibitor tti-101::TTI-101::TTI101::Tti 101::Tti-101

SMILES COc1ccc(cc1)S(=O)(=O)Nc1cc(c(O)c2ccccc12)-c1c(O)ccc2ccccc12

InChI Key InChIKey=QDCJDYWGYVPBDO-UHFFFAOYSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50605550   

TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50605550(C-188-9 | Stat3 inhibitor c188-9 | Stat3 inhibitor...)
Affinity DataKd:  250nMAssay Description:Binding affinity to full length STAT3 (unknown origin) by Surface plasmon resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50605550(C-188-9 | Stat3 inhibitor c188-9 | Stat3 inhibitor...)
Affinity DataKd:  4.70nMAssay Description:Binding affinity to STAT3 (127 to 722 residues) (unknown origin) by microscale thermophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50605550(C-188-9 | Stat3 inhibitor c188-9 | Stat3 inhibitor...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of STAT3 in human KG-1 cells assessed as inhibition of G-CSF induced STAT3 phosphorylation incubated for 60 mins by western blot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50605550(C-188-9 | Stat3 inhibitor c188-9 | Stat3 inhibitor...)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of STAT3 in human NB-4 cells assessed as inhibition of G-CSF induced STAT3 phosphorylation incubated for 60 mins by western blot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50605550(C-188-9 | Stat3 inhibitor c188-9 | Stat3 inhibitor...)
Affinity DataIC50: 4.00E+3nMAssay Description:Binding affinity to STAT3 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed