BDBM50176259 (1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol::CHEMBL201531::TRAMADOL

SMILES COc1cccc(c1)[C@@]1(O)CCCC[C@@H]1CN(C)C

InChI Key InChIKey=TVYLLZQTGLZFBW-UHFFFAOYSA-N

Data  8 KI  17 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50176259   

TargetSodium-dependent serotonin transporter(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of reuptake of 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University Medicine Greifswald

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataIC50: 8.88E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataEC50:  1.30E+3nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 1 hr by HTRF ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSolute carrier family 22 member 1(Human)
University Medicine Greifswald

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataIC50: 5.25E+4nMAssay Description:Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataIC50: 3.86E+3nMAssay Description:Inhibition of NET mediated norepinephrine uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of SERT mediated 5-hydroxytryptamine uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataIC50: 7.60E+3nMAssay Description:Binding affinity to mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of reuptake of NorepinephrineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of reuptake of 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of reuptake of NorepinephrineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of reuptake of 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of reuptake of NorepinephrineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of reuptake of 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataIC50: 790nMAssay Description:Inhibition of reuptake of NorepinephrineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human MOR expressed in CHO cell membranes after 60 mins by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataKi:  9.40nMAssay Description:Displacement of [3H]Naltrindole form human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataKi:  14nMAssay Description:Activity at human cloned kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataKi:  1.60E+3nMAssay Description:Activity at human cloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataKi:  2.00E+3nMAssay Description:Opioid receptor mu 1 agonist activity with monoamine (NE, 5-HT) uptake-blocking activity in the 0.8-1 uM rangeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Wroclaw Medical University

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataKi:  2.40E+3nMAssay Description:Displacement of [3H]-dihydromorphine from mu opioid receptor in rat cerebral cortex by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataKi:  2.40E+3nMAssay Description:Displacement of [3H]naloxone from human MOR expressed in CHO-K1 cell membranes after 60 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]DPDPE from human DOR expressed in CHO cell membranes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50176259(TRAMADOL | (1R,2R)-2-[(dimethylamino)methyl]-1-(3-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]U69593 from human KOR expressed in CHO cell membranes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details Article
PubMed