BDBM50143800 5-Isopropyl-pyridine-2-sulfonic acid {6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-[2-(1H-tetrazol-5-yl)-pyridin-4-yl]-pyrimidin-4-yl}-amide::CHEMBL61780::TEZOSENTAN

SMILES COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(cn2)C(C)C)nc(nc1OCCO)-c1ccnc(c1)-c1nnn[nH]1

InChI Key InChIKey=TUYWTLTWNJOZNY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50143800   

TargetEndothelin-1 receptor(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143800(CHEMBL61780 | 5-Isopropyl-pyridine-2-sulfonic acid...)
Affinity DataIC50: 18nMAssay Description:Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143800(CHEMBL61780 | 5-Isopropyl-pyridine-2-sulfonic acid...)
Affinity DataIC50: 18nMAssay Description:Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143800(CHEMBL61780 | 5-Isopropyl-pyridine-2-sulfonic acid...)
Affinity DataIC50: 21nMAssay Description:Displacement of radioligand from ETB receptor in human placenta cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143800(CHEMBL61780 | 5-Isopropyl-pyridine-2-sulfonic acid...)
Affinity DataIC50: 21nMAssay Description:Displacement of radioligand from ETB receptor in human placenta cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Rat)
Encysive Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50143800(CHEMBL61780 | 5-Isopropyl-pyridine-2-sulfonic acid...)
Affinity DataIC50: 23nMAssay Description:Displacement of [125I]ET-1 from Endothelin A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed