BDBM50593765 MUBRITINIB::Mubritinib::TAK-165

SMILES FC(F)(F)c1ccc(\C=C\c2nc(COc3ccc(CCCCn4ccnn4)cc3)co2)cc1

InChI Key InChIKey=ZTFBIUXIQYRUNT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50593765   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
China Medical University

Curated by ChEMBL
LigandPNGBDBM50593765(Mubritinib | TAK-165 | MUBRITINIB)
Affinity DataIC50: 350nMAssay Description:Inhibition of human HER2 incubated for 25 mins by ADP-Glo reagent based microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
China Medical University

Curated by ChEMBL
LigandPNGBDBM50593765(Mubritinib | TAK-165 | MUBRITINIB)
Affinity DataIC50: 51nMAssay Description:Inhibition of ERBB2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
China Medical University

Curated by ChEMBL
LigandPNGBDBM50593765(Mubritinib | TAK-165 | MUBRITINIB)
Affinity DataIC50: 80nMAssay Description:Inhibition of ERBB2 (unknown origin) in human NCI-H1975 cells assessed as increase in mitochondrial ROS level incubated for 48 hrs by Western blot an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed