BDBM50074893 2-[4-(6,7-Diethoxy-2,3-bis-hydroxymethyl-naphthalen-1-yl)-pyridin-2-yl]-4-pyridin-3-yl-2H-phthalazin-1-one; hydrochloride::CHEMBL557593::T-2585.HCl

SMILES CCOc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OCC

InChI Key InChIKey=OEZADIAHVKNQKD-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50074893   

LigandPNGBDBM50074893(2-[4-(6,7-Diethoxy-2,3-bis-hydroxymethyl-naphthale...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of guinea pig lung Phosphodiesterase 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50074893(2-[4-(6,7-Diethoxy-2,3-bis-hydroxymethyl-naphthale...)
Affinity DataIC50: 1.80E+3nMAssay Description:In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50074893(2-[4-(6,7-Diethoxy-2,3-bis-hydroxymethyl-naphthale...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Phosphodiesterase 1 of guinea pig cardiac ventricleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50074893(2-[4-(6,7-Diethoxy-2,3-bis-hydroxymethyl-naphthale...)
Affinity DataIC50: 200nMAssay Description:Inhibition of Phosphodiesterase 5 of guinea pig lungMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50074893(2-[4-(6,7-Diethoxy-2,3-bis-hydroxymethyl-naphthale...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of guinea pig cardiac ventricle Phosphodiesterase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50074893(2-[4-(6,7-Diethoxy-2,3-bis-hydroxymethyl-naphthale...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human recombinant FLAG-tagged PDE7A expressed in African green monkey COS7 cells using [3H]cAMP as substrate after 30 mins by scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50074893(2-[4-(6,7-Diethoxy-2,3-bis-hydroxymethyl-naphthale...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]- rolipram binding to guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed