BDBM50168995 (-)-swainsonine::(1S,2R,8R,8aR)-Octahydro-indolizine-1,2,8-triol::1S-8AB-OCTAHYDRO-INDOLIZIDINE-1A,2A,8B-TRIOL::CHEMBL371197::SWAINSONINE

SMILES O[C@@H]1CN2CCC[C@@H](O)[C@@H]2[C@@H]1O

InChI Key InChIKey=FXUAIOOAOAVCGD-UHFFFAOYSA-N

Data  4 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50168995   

Targetalpha-1,2-Mannosidase(Soybean)
Institute of Chemical Sciences and Engineering

Curated by ChEMBL
LigandPNGBDBM50168995((-)-swainsonine | CHEMBL371197 | (1S,2R,8R,8aR)-Oc...)
Affinity DataIC50: 400nMAssay Description:Concentration of compound inhibiting alpha-Mannosidase isolated from Jack beanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50168995((-)-swainsonine | CHEMBL371197 | (1S,2R,8R,8aR)-Oc...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of alpha-mannosidase in human LNZ308 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50168995((-)-swainsonine | CHEMBL371197 | (1S,2R,8R,8aR)-Oc...)
Affinity DataIC50: 50nMAssay Description:Inhibition of alpha-mannosidase in human LN18 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetLysosomal alpha-mannosidase(Human)
Ecole Polytechnique FéDéRale De Lausanne

Curated by ChEMBL
LigandPNGBDBM50168995((-)-swainsonine | CHEMBL371197 | (1S,2R,8R,8aR)-Oc...)
Affinity DataIC50: 10nMAssay Description:Inhibition of alpha-mannosidase in human HCECMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMannosyl-oligosaccharide alpha-1,2-mannosidase IA(Fruit fly)
Slovak Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50168995((-)-swainsonine | CHEMBL371197 | (1S,2R,8R,8aR)-Oc...)
Affinity DataIC50: 5nMAssay Description:Inhibition of Drosophila melanogaster GM2b by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50168995((-)-swainsonine | CHEMBL371197 | (1S,2R,8R,8aR)-Oc...)
Affinity DataIC50: 1.15E+6nMAssay Description:Inhibition of HIV1 RTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Fruit fly)
University of Toronto

LigandPNGBDBM50168995((-)-swainsonine | CHEMBL371197 | (1S,2R,8R,8aR)-Oc...)
Affinity DataKi:  3nM ΔG°:  -11.6kcal/mole IC50: 37nMpH: 5.75 T: 2°CAssay Description:Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/14/2012
Entry Details Article
PubMed
TargetMannosyl-oligosaccharide alpha-1,2-mannosidase IA(Fruit fly)
Slovak Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50168995((-)-swainsonine | CHEMBL371197 | (1S,2R,8R,8aR)-Oc...)
Affinity DataKi:  3nMAssay Description:Inhibition of Drosophila melanogaster GM2b by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2013
Entry Details Article
PubMed
TargetAlpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50168995((-)-swainsonine | CHEMBL371197 | (1S,2R,8R,8aR)-Oc...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 3990 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetAlpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50168995((-)-swainsonine | CHEMBL371197 | (1S,2R,8R,8aR)-Oc...)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 2199 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed