BDBM163635 SR-3298::US10807944, Compound RLS2-225::US11731934, Compound RLS2-225

SMILES CN(C)c1ccc(cc1)C(=O)NNCC1CCCC1

InChI Key InChIKey=LJBJHPWKSLDVNC-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 163635   

TargetHistone deacetylase 1/Nuclear receptor corepressor 2 [395-498](Human)
University of Florida College of Medicine

LigandPNGBDBM163635(SR-3298 | US10807944, Compound RLS2-225 | US117319...)
Affinity DataIC50: 1.76E+3nMAssay Description:Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395 498)) were obtained from BPS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2016
Entry Details Article
PubMed
TargetHistone deacetylase 2/Nuclear receptor corepressor 2 [395-498](Human)
University of Florida College of Medicine

LigandPNGBDBM163635(SR-3298 | US10807944, Compound RLS2-225 | US117319...)
Affinity DataIC50: 3.25E+3nMAssay Description:Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395 498)) were obtained from BPS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2016
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 [395-498](Human)
University of Florida College of Medicine

LigandPNGBDBM163635(SR-3298 | US10807944, Compound RLS2-225 | US117319...)
Affinity DataIC50: 1.67E+3nMAssay Description:Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395 498)) were obtained from BPS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2016
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Florida Research Foundation

US Patent
LigandPNGBDBM163635(SR-3298 | US10807944, Compound RLS2-225 | US117319...)
Affinity DataIC50: 1.76E+3nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
University of Florida Research Foundation

US Patent
LigandPNGBDBM163635(SR-3298 | US10807944, Compound RLS2-225 | US117319...)
Affinity DataIC50: 3.25E+3nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
University of Florida Research Foundation

US Patent
LigandPNGBDBM163635(SR-3298 | US10807944, Compound RLS2-225 | US117319...)
Affinity DataIC50: 1.67E+3nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
University of Florida Research Foundation

US Patent
LigandPNGBDBM163635(SR-3298 | US10807944, Compound RLS2-225 | US117319...)
Affinity DataIC50: 1.76E+3nMAssay Description:Inhibition of HDAC1 (unknown origin) using acetylated 7-amino-4-methylcoumarin (AMC) as peptide substrate measured after 20 mins by fluorescence base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
University of Florida Research Foundation

US Patent
LigandPNGBDBM163635(SR-3298 | US10807944, Compound RLS2-225 | US117319...)
Affinity DataIC50: 3.25E+3nMAssay Description:Inhibition of HDAC2 (unknown origin) using acetylated 7-amino-4-methylcoumarin (AMC) as peptide substrate measured after 20 mins by fluorescence base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
University of Florida Research Foundation

US Patent
LigandPNGBDBM163635(SR-3298 | US10807944, Compound RLS2-225 | US117319...)
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibition of HDAC3 (unknown origin) using acetylated 7-amino-4-methylcoumarin (AMC) as peptide substrate measured after 20 mins by fluorescence base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Florida Research Foundation

US Patent
LigandPNGBDBM163635(SR-3298 | US10807944, Compound RLS2-225 | US117319...)
Affinity DataIC50: 1.76E+3nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
University of Florida Research Foundation

US Patent
LigandPNGBDBM163635(SR-3298 | US10807944, Compound RLS2-225 | US117319...)
Affinity DataIC50: 3.25E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
University of Florida Research Foundation

US Patent
LigandPNGBDBM163635(SR-3298 | US10807944, Compound RLS2-225 | US117319...)
Affinity DataIC50: 1.67E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2023
Entry Details
Go to US Patent