BDBM50064172 1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydro-2'H-thiochromene)]::CHEMBL39900::SPIPETHIANE

SMILES C(N1CCC2(CC1)CCc1ccccc1S2)c1ccccc1

InChI Key InChIKey=FPSFVONLLBIZFK-UHFFFAOYSA-N

Data  12 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50064172   

TargetSigma non-opioid intracellular receptor 1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50064172(CHEMBL39900 | 1-benzylspiro[hexahydropyridine-4,2'...)
Affinity DataKi:  0.5nMAssay Description:Compound was tested for its binding affinity towards sigma 1 receptor using [3H](+)-pentazocine from guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50064172(CHEMBL39900 | 1-benzylspiro[hexahydropyridine-4,2'...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor in rat liver membranes incubated for 60 mins in presence of [3H]DTG by radioactivity metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50064172(CHEMBL39900 | 1-benzylspiro[hexahydropyridine-4,2'...)
Affinity DataKi:  0.589nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in human Jurkat cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Human)
Universit£

Curated by ChEMBL
LigandPNGBDBM50064172(CHEMBL39900 | 1-benzylspiro[hexahydropyridine-4,2'...)
Affinity DataKi:  6.40nMAssay Description:Binding affinity to S2R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50064172(CHEMBL39900 | 1-benzylspiro[hexahydropyridine-4,2'...)
Affinity DataKi:  9.20nMAssay Description:Binding affinity to S1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50064172(CHEMBL39900 | 1-benzylspiro[hexahydropyridine-4,2'...)
Affinity DataKi:  416nMAssay Description:Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes incubated for 60 mins in presence of [3H]-(+)-pentazocine by radioactivity metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50064172(CHEMBL39900 | 1-benzylspiro[hexahydropyridine-4,2'...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for its binding affinity towards Alpha-1B adrenergic receptor using [3H]prazosin from rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50064172(CHEMBL39900 | 1-benzylspiro[hexahydropyridine-4,2'...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M3 using [3H]NMS from rat submaxillary glandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50064172(CHEMBL39900 | 1-benzylspiro[hexahydropyridine-4,2'...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for its binding affinity towards PCP receptor using [3H](+)-NANM in the presence of 5 uM haloperidol from rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50064172(CHEMBL39900 | 1-benzylspiro[hexahydropyridine-4,2'...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for its binding affinity towards Alpha-1A adrenergic receptor using [3H]prazosin from rat submaxillary glandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50064172(CHEMBL39900 | 1-benzylspiro[hexahydropyridine-4,2'...)
Affinity DataKi:  1.04E+4nMAssay Description:Compound was tested for its binding affinity towards Dopamine receptor D2 using [3H]spiperone from rat striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50064172(CHEMBL39900 | 1-benzylspiro[hexahydropyridine-4,2'...)
Affinity DataKi:  1.08E+4nMAssay Description:Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heartMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed