BDBM103827 SPI-02::US11041859, Code SPI-02::US9791447, Compound SPI-02

SMILES Cc1cc(ccc1\N=N\c1c(N)ccc2cc(ccc12)S(O)(=O)=O)-c1ccc(\N=N\c2c(N)c(cc3cc(ccc23)S(O)(=O)=O)S(O)(=O)=O)c(C)c1

InChI Key InChIKey=OFGVQLJUXSRVEG-UHFFFAOYSA-N

Data  20 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 103827   

LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.70E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
Go to US Patent

TargetSentrin-specific protease 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of SENP3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSentrin-specific protease 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of SENP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSentrin-specific protease 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of SENP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSentrin-specific protease 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of His-tagged human SENP7 expressed in Escherichia coli (DE3) using YFP-SUMO-ECFP as substrate incubated for 15 mins by Coomassie staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSentrin-specific protease 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of His-tagged human SENP2 (364 to 589 residues) expressed in Escherichia coli (DE3) using YFP-SUMO-ECFP as substrate incubated for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSentrin-specific protease 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of His-tagged human SENP1 (419 to 644 residues) expressed in Escherichia coli (DE3) using YFP-SUMO-ECFP as substrate incubated for 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSentrin-specific protease 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.70E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
Go to US Patent

TargetSentrin-specific protease 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.00E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
Go to US Patent

TargetSentrin-specific protease 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.10E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
Go to US Patent

TargetSentrin-specific protease 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.65E+4nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2014
Entry Details Article
PubMed
TargetSmall ubiquitin-related modifier 1/2(Human)
City of Hope

US Patent
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.08E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
Go to US Patent

LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 3.42E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
Go to US Patent

LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.65E+4nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
Go to US Patent

TargetSentrin-specific protease 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.70E+3nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent

TargetSentrin-specific protease 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.00E+3nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent

TargetSentrin-specific protease 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.10E+3nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent

TargetSentrin-specific protease 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.70E+3nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2014
Entry Details Article
PubMed
TargetSentrin-specific protease 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 2.08E+3nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2014
Entry Details Article
PubMed
TargetSentrin-specific protease 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103827(SPI-02 | US9791447, Compound SPI-02 | US11041859, ...)
Affinity DataIC50: 3.42E+3nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2014
Entry Details Article
PubMed