BDBM50433916 PS653 ('1,6-dihydrodibenzo[c,d,g]indazol-6-one)::SP-600125

SMILES O=C1c2ccccc2-c2[nH]nc3cccc1c23

InChI Key InChIKey=ACPOUJIDANTYHO-UHFFFAOYSA-N

Data  4 IC50  1 Kd  1 ITC

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50433916   

Target3-phosphoinositide-dependent protein kinase 1 [50-359](Human)
Universitätsklinikum Frankfurt

LigandPNGBDBM50433916(SP-600125 | PS653 ('1,6-dihydrodibenzo[c,d,g]i...)
Affinity DataKd:  1.25E+3nMpH: 7.4Assay Description:Titrations were performed by a 0.4 µl injection followed by 19 successive injections (2 µl) of each compound(adenosine 500 µM, PS653 250 µM) into a 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50433916(SP-600125 | PS653 ('1,6-dihydrodibenzo[c,d,g]i...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50433916(SP-600125 | PS653 ('1,6-dihydrodibenzo[c,d,g]i...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50433916(SP-600125 | PS653 ('1,6-dihydrodibenzo[c,d,g]i...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50433916(SP-600125 | PS653 ('1,6-dihydrodibenzo[c,d,g]i...)
Affinity DataIC50: 98nMAssay Description:Inhibition of MPS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 50433916   

Cell3-phosphoinositide dependent protein kinase-1(Human)
Universitätsklinikum Frankfurt

SyringePNGBDBM50433916(SP-600125 | PS653 ('1,6-dihydrodibenzo[c,d,g]i...)
ITC DataΔG°: -8.37kcal/mole −TΔS°: -7.19kcal/mole ΔH°: -1.20kcal/mole logk: 8.00E+5
T: 36.85°C 
In DepthDetails Article
PubMed