BDBM50176019 (R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)propyl)piperazin-1-yl)-2-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one::(R)-8-{4-[3-(5-Fluoro-1H-indol-3-yl)-propyl]-piperazin-1-yl}-2-methyl-4H-benzo[1,4]oxazin-3-one::CHEMBL196514::SLV-314

SMILES C[C@H]1Oc2c(NC1=O)cccc2N1CCN(CCCc2c[nH]c3ccc(F)cc23)CC1

InChI Key InChIKey=SDAMYSWGWHXMRT-UHFFFAOYSA-N

Data  13 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50176019   

TargetSodium-dependent serotonin transporter(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019(SLV-314 | (R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)prop...)
Affinity DataKi:  0.200nMAssay Description:In vitro inhibitory constant against [3H]paroxetine binding to rat frontal cortex membrane serotonin reuptake siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019(SLV-314 | (R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)prop...)
Affinity DataKi:  0.251nMAssay Description:Displacement of [3H]paraxetine from human 5HT transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019(SLV-314 | (R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)prop...)
Affinity DataKi:  0.501nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019(SLV-314 | (R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)prop...)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]spiperone from human dopamine D2 receptor short form expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019(SLV-314 | (R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)prop...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019(SLV-314 | (R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)prop...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]spiperone from human dopamine D4.4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019(SLV-314 | (R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)prop...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019(SLV-314 | (R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)prop...)
Affinity DataKi:  6.90nMAssay Description:In vitro inhibitory constant against [3H]spiperone binding to human dopamine D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019(SLV-314 | (R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)prop...)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019(SLV-314 | (R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)prop...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]prazosin from adrenergic alpha1 receptor in rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019(SLV-314 | (R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)prop...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019(SLV-314 | (R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)prop...)
Affinity DataKi:  126nMAssay Description:Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50176019(SLV-314 | (R)-8-(4-(3-(5-fluoro-1H-indol-3-yl)prop...)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]mesulergine from 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed