BDBM119878 SL827::US9073941, 500

SMILES C[N@@](CC(=O)Nc1ccc(cc1)OC)S(=O)(=O)c2cc(cnc2N)Br

InChI Key InChIKey=HMNYMNWOUAJOIH-UHFFFAOYSA-N

Data  2 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 119878   

TargetDihydrolipoyl dehydrogenase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Academia Sinica

US Patent
LigandPNGBDBM119878(SL827 | US9073941, 500)
Affinity DataIC50: 960nMpH: 7.0Assay Description:The assay was performed in a manner similar to that described in Bryk et al., Biochemistry (2010) 49:1616-1627 and modified for an online robotics sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2016
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetDihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Academia Sinica

US Patent
LigandPNGBDBM119878(SL827 | US9073941, 500)
Affinity DataIC50: 674nMpH: 7.0Assay Description:Mtb PDH (Lpd+DlaT+AceE) is provided by Dr. Bryk Ruslana. The assay was performed in a manner similar to that described in Bryk et al., Biochemistry (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2016
Entry Details
Go to US Patent

TargetDihydrolipoyl dehydrogenase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Weill Cornell Medical College

LigandPNGBDBM119878(SL827 | US9073941, 500)
Affinity DataKi:  140nMAssay Description:IC50 values were determined with serial dilutions (from 100 to 0.1 uM) of inhibitors by a spectrophotometric assay with DTNB, lipoamide, and NADH or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPrephenate dehydrogenase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Weill Cornell Medical College

LigandPNGBDBM119878(SL827 | US9073941, 500)
Affinity DataKi:  155nMAssay Description:IC50 values were determined with serial dilutions (from 100 to 0.1 uM) of inhibitors by a spectrophotometric assay with DTNB, lipoamide, and NADH or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2014
Entry Details Article
PubMed