BDBM50068132 3-[(4-Benzyl-piperazin-1-yl)-(4-tert-butyl-phenyl)-methyl]-phenol::CHEMBL143592::SL-3111

SMILES CC(C)(C)c1ccc(cc1)C(N1CCN(Cc2ccccc2)CC1)c1cccc(O)c1

InChI Key InChIKey=PNVIEMCZBRMSPB-UHFFFAOYSA-N

Data  8 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50068132   

TargetMu-type opioid receptor(Guinea pig)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50068132(SL-3111 | 3-[(4-Benzyl-piperazin-1-yl)-(4-tert-but...)
Affinity DataEC50:  3.90E+4nMAssay Description:Tested for electrically induced smooth muscle contractions from guinea pig ileum expressed in mu opioid receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50068132(SL-3111 | 3-[(4-Benzyl-piperazin-1-yl)-(4-tert-but...)
Affinity DataIC50: 5.5nMAssay Description:Binding affinity was measured against cloned human Opioid receptor delta 1 (wild-type,Wt)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50068132(SL-3111 | 3-[(4-Benzyl-piperazin-1-yl)-(4-tert-but...)
Affinity DataEC50:  7.60E+3nMAssay Description:Tested for electrically induced smooth muscle contractions from guinea pig ileum expressed in mu opioid receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50068132(SL-3111 | 3-[(4-Benzyl-piperazin-1-yl)-(4-tert-but...)
Affinity DataEC50:  210nMAssay Description:Tested for electrically induced smooth muscle contractions from mouse vas deferens expressed in delta opioid receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50068132(SL-3111 | 3-[(4-Benzyl-piperazin-1-yl)-(4-tert-but...)
Affinity DataIC50: 8.40nMAssay Description:Binding affinity was measured against Opioid receptor delta 1 using [3H]p-Cl-DPDPE as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50068132(SL-3111 | 3-[(4-Benzyl-piperazin-1-yl)-(4-tert-but...)
Affinity DataIC50: 1.10E+4nMAssay Description:Binding affinity was measured against Opioid receptor mu 1 using [3H]-DAMGO as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50068132(SL-3111 | 3-[(4-Benzyl-piperazin-1-yl)-(4-tert-but...)
Affinity DataIC50: 17nMAssay Description:Binding affinity was measured against mutated human Opioid receptor delta 1 (W248L)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50068132(SL-3111 | 3-[(4-Benzyl-piperazin-1-yl)-(4-tert-but...)
Affinity DataEC50:  210nMAssay Description:Tested for electrically induced smooth muscle contractions from mouse vas deferens expressed in delta opioid receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50068132(SL-3111 | 3-[(4-Benzyl-piperazin-1-yl)-(4-tert-but...)
Affinity DataIC50: 1.10E+4nMAssay Description:Binding affinity was measured against Opioid receptor mu 1 using [3H]-DAMGO as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50068132(SL-3111 | 3-[(4-Benzyl-piperazin-1-yl)-(4-tert-but...)
Affinity DataIC50: 8.40nMAssay Description:Binding affinity was measured against Opioid receptor delta 1 using [3H]p-Cl-DPDPE as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50068132(SL-3111 | 3-[(4-Benzyl-piperazin-1-yl)-(4-tert-but...)
Affinity DataIC50: 1.70E+4nMAssay Description:In vitro inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 using rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50068132(SL-3111 | 3-[(4-Benzyl-piperazin-1-yl)-(4-tert-but...)
Affinity DataIC50: 8.40nMAssay Description:In vitro inhibition of [3H]deltorphin binding to Opioid receptor delta 1 using rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed