BDBM50004918 (+/-)-APD3-Allyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol::3-Allyl-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrochloride::CHEMBL288090::CHEMBL552611::SKF 77434

SMILES Oc1cc2CCN(CC=C)CC(c3ccccc3)c2cc1O

InChI Key InChIKey=QBUVZVXIRYFENV-UHFFFAOYSA-N

Data  11 KI  2 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50004918   

TargetD(1A) dopamine receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50004918(CHEMBL288090 | 3-Allyl-1-phenyl-2,3,4,5-tetrahydro...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50004918(CHEMBL288090 | 3-Allyl-1-phenyl-2,3,4,5-tetrahydro...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50004918(CHEMBL288090 | 3-Allyl-1-phenyl-2,3,4,5-tetrahydro...)
Affinity DataEC50: >1.00E+4nMAssay Description:Dopamine receptor D2 agonist activity was determined for inhibition of release of NE in an isolated perfused rabbit ear artery preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50004918(CHEMBL288090 | 3-Allyl-1-phenyl-2,3,4,5-tetrahydro...)
Affinity DataEC50:  25nMAssay Description:Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Research Biochemicals

Curated by ChEMBL
LigandPNGBDBM50004918(CHEMBL288090 | 3-Allyl-1-phenyl-2,3,4,5-tetrahydro...)
Affinity DataIC50: 2.43E+3nMAssay Description:Displacement of [3H]YM-09151-2 (60 pm) from dopamine receptor D2 in crude membrane fraction of rat brain corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50004918(CHEMBL288090 | 3-Allyl-1-phenyl-2,3,4,5-tetrahydro...)
Affinity DataIC50: 20nMAssay Description:Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50004918(CHEMBL288090 | 3-Allyl-1-phenyl-2,3,4,5-tetrahydro...)
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetD(1A) dopamine receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50004918(CHEMBL288090 | 3-Allyl-1-phenyl-2,3,4,5-tetrahydro...)
Affinity DataKi:  10.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50004918(CHEMBL288090 | 3-Allyl-1-phenyl-2,3,4,5-tetrahydro...)
Affinity DataKi:  12nMAssay Description:The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Shanghaitech University

Curated by ChEMBL
LigandPNGBDBM50004918(CHEMBL288090 | 3-Allyl-1-phenyl-2,3,4,5-tetrahydro...)
Affinity DataKi:  73nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50004918(CHEMBL288090 | 3-Allyl-1-phenyl-2,3,4,5-tetrahydro...)
Affinity DataKi:  580nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
TargetAlpha-2C adrenergic receptor(Rat)
Harvard University

Curated by PDSP Ki Database
LigandPNGBDBM50004918(CHEMBL288090 | 3-Allyl-1-phenyl-2,3,4,5-tetrahydro...)
Affinity DataKi:  632nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Research Biochemicals

Curated by ChEMBL
LigandPNGBDBM50004918(CHEMBL288090 | 3-Allyl-1-phenyl-2,3,4,5-tetrahydro...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50004918(CHEMBL288090 | 3-Allyl-1-phenyl-2,3,4,5-tetrahydro...)
Affinity DataKi:  2.11E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50004918(CHEMBL288090 | 3-Allyl-1-phenyl-2,3,4,5-tetrahydro...)
Affinity DataKi:  2.70E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50004918(CHEMBL288090 | 3-Allyl-1-phenyl-2,3,4,5-tetrahydro...)
Affinity DataKi:  3.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM50004918(CHEMBL288090 | 3-Allyl-1-phenyl-2,3,4,5-tetrahydro...)
Affinity DataKi:  3.04E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details
PubMed