BDBM50084141 (E)-2-methyl-6-styrylpyridine::2-Methyl-6-((E)-styryl)-pyridine::2-Methyl-6-styryl-pyridine(SIB-1893)::CHEMBL88612::SIB-1757

SMILES Cc1cccc(\C=C\c2ccccc2)n1

InChI Key InChIKey=SISOFUCTXZKSOQ-UHFFFAOYSA-N

Data  8 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50084141   

TargetMetabotropic glutamate receptor 1(Human)
Universit¿A Di Perugia

Curated by ChEMBL
LigandPNGBDBM50084141((E)-2-methyl-6-styrylpyridine | SIB-1757 | 2-Methy...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound was tested for its agonist activity against Ser165 and Thr188 (Metabotropic glutamate receptor 1) receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLuciferin 4-monooxygenase(Common eastern firefly)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50084141((E)-2-methyl-6-styrylpyridine | SIB-1757 | 2-Methy...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of Photinus pyralis luciferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetLuciferin 4-monooxygenase(Common eastern firefly)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50084141((E)-2-methyl-6-styrylpyridine | SIB-1757 | 2-Methy...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Photinus pyralis luciferase by Steady-Glo reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetLuciferin 4-monooxygenase(Common eastern firefly)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50084141((E)-2-methyl-6-styrylpyridine | SIB-1757 | 2-Methy...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of Photinus pyralis luciferase by BrightGlo reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetLuciferin 4-monooxygenase(Common eastern firefly)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50084141((E)-2-methyl-6-styrylpyridine | SIB-1757 | 2-Methy...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of Photinus pyralis luciferase by Easy lite assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetLuciferin 4-monooxygenase(Common eastern firefly)
National Human Genome Research Institute

Curated by ChEMBL
LigandPNGBDBM50084141((E)-2-methyl-6-styrylpyridine | SIB-1757 | 2-Methy...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of Photinus pyralis luciferase by PK-Light assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50084141((E)-2-methyl-6-styrylpyridine | SIB-1757 | 2-Methy...)
Affinity DataIC50: 3.00E+3nMAssay Description:In vitro for inhibitory activity of compound against recombinant Metabotropic glutamate receptor 5 evaluated as inhibition of quisqualate-stimulated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50084141((E)-2-methyl-6-styrylpyridine | SIB-1757 | 2-Methy...)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of [3H]MPEP binding to mGluR5 in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50084141((E)-2-methyl-6-styrylpyridine | SIB-1757 | 2-Methy...)
Affinity DataIC50: 290nMAssay Description:Compound was tested for it's antagonist activity against Ser152 and Thr175 (Metabotropic glutamate receptor 5)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50084141((E)-2-methyl-6-styrylpyridine | SIB-1757 | 2-Methy...)
Affinity DataIC50: 1.10E+3nMAssay Description:In vitro for inhibitory activity of compound against recombinant Metabotropic glutamate receptor 5 evaluated as inhibition of quisqualate-stimulated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50084141((E)-2-methyl-6-styrylpyridine | SIB-1757 | 2-Methy...)
Affinity DataKi:  290nMAssay Description:Agonist potency against cloned metabotropic glutamate receptor 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50084141((E)-2-methyl-6-styrylpyridine | SIB-1757 | 2-Methy...)
Affinity DataKi:  2.60E+4nMAssay Description:Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50084141((E)-2-methyl-6-styrylpyridine | SIB-1757 | 2-Methy...)
Affinity DataKi: >1.00E+5nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50084141((E)-2-methyl-6-styrylpyridine | SIB-1757 | 2-Methy...)
Affinity DataKi: >1.00E+5nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 3 (mGluR-3).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50084141((E)-2-methyl-6-styrylpyridine | SIB-1757 | 2-Methy...)
Affinity DataKi: >1.00E+5nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50084141((E)-2-methyl-6-styrylpyridine | SIB-1757 | 2-Methy...)
Affinity DataKi: >1.00E+5nMAssay Description:Antagonist potency against cloned Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50084141((E)-2-methyl-6-styrylpyridine | SIB-1757 | 2-Methy...)
Affinity DataKi: >1.00E+5nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 7 (mGluR-7).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Universit¿A Di Perugia

Curated by ChEMBL
LigandPNGBDBM50084141((E)-2-methyl-6-styrylpyridine | SIB-1757 | 2-Methy...)
Affinity DataKi: >1.00E+5nMAssay Description:Agonist potency against cloned human metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed