BDBM50001610 7-[3-(4-Acetyl-3-methoxy-2-propyl-phenoxy)-propoxy]-8-propyl-chroman-2-carboxylic acid::7-[3-(4-Acetyl-3-methoxy-2-propyl-phenoxy)-propoxy]-8-propyl-chroman-2-carboxylic acid (SC41930)::CGS 24115::CHEMBL14823::SC-41930

SMILES CCCc1c(OCCCOc2ccc3CCC(Oc3c2CCC)C(O)=O)ccc(C(C)=O)c1OC

InChI Key InChIKey=ZVVCSBSDFGYRCB-UHFFFAOYSA-N

Data  5 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50001610   

TargetLeukotriene B4 receptor 1(Human)
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001610(CHEMBL14823 | CGS 24115 | 7-[3-(4-Acetyl-3-methoxy...)
Affinity DataIC50: 300nMAssay Description:Concentration inhibiting the binding of [3H]LTB4 to human neutrophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001610(CHEMBL14823 | CGS 24115 | 7-[3-(4-Acetyl-3-methoxy...)
Affinity DataIC50: 300nMAssay Description:Compound was evaluated in a human neutrophil leukotriene B4 receptor binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001610(CHEMBL14823 | CGS 24115 | 7-[3-(4-Acetyl-3-methoxy...)
Affinity DataIC50: 43nMAssay Description:Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001610(CHEMBL14823 | CGS 24115 | 7-[3-(4-Acetyl-3-methoxy...)
Affinity DataIC50: 320nMAssay Description:Binding affinity for Leukotriene B4 (LTB4) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001610(CHEMBL14823 | CGS 24115 | 7-[3-(4-Acetyl-3-methoxy...)
Affinity DataIC50: 300nMAssay Description:Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001610(CHEMBL14823 | CGS 24115 | 7-[3-(4-Acetyl-3-methoxy...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against leukotriene B4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetLeukotriene B4 receptor 1(Human)
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001610(CHEMBL14823 | CGS 24115 | 7-[3-(4-Acetyl-3-methoxy...)
Affinity DataIC50: 20nMAssay Description:Compound was tested for inhibitory activity against LTB4 (leukotriene) bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001610(CHEMBL14823 | CGS 24115 | 7-[3-(4-Acetyl-3-methoxy...)
Affinity DataIC50: 140nMAssay Description:In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

LigandPNGBDBM50001610(CHEMBL14823 | CGS 24115 | 7-[3-(4-Acetyl-3-methoxy...)
Affinity DataIC50: 200nMAssay Description:Inhibition of specific binding of [3H]LTB4 to LTB4 receptor in human neutrophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2018
Entry Details

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sultan Moulay Slimane University

Curated by ChEMBL
LigandPNGBDBM50001610(CHEMBL14823 | CGS 24115 | 7-[3-(4-Acetyl-3-methoxy...)
Affinity DataIC50: 300nMAssay Description:Antagonist activity against LTB4 receptor in human Neutrophil incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
LigandPNGBDBM50001610(CHEMBL14823 | CGS 24115 | 7-[3-(4-Acetyl-3-methoxy...)
Affinity DataKi:  15nMAssay Description:Inhibition of specific binding of [3H]-LTB4 to LTB4 receptor in guinea pig lung membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2018
Entry Details

TargetLeukotriene B4 receptor 2(Human)
Ciba-Geigy

Curated by PDSP Ki Database
LigandPNGBDBM50001610(CHEMBL14823 | CGS 24115 | 7-[3-(4-Acetyl-3-methoxy...)
Affinity DataKi:  131nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2011
Entry Details
PubMed
TargetLeukotriene B4 receptor 2(Human)
Ciba-Geigy

Curated by PDSP Ki Database
LigandPNGBDBM50001610(CHEMBL14823 | CGS 24115 | 7-[3-(4-Acetyl-3-methoxy...)
Affinity DataKi:  137nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2011
Entry Details
PubMed
TargetLeukotriene B4 receptor 1(Human)
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001610(CHEMBL14823 | CGS 24115 | 7-[3-(4-Acetyl-3-methoxy...)
Affinity DataKi:  220nMAssay Description:Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLeukotriene B4 receptor 1(Human)
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001610(CHEMBL14823 | CGS 24115 | 7-[3-(4-Acetyl-3-methoxy...)
Affinity DataKi:  280nMAssay Description:In vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article