BDBM50423648 CHEMBL1334465::SB-408124

SMILES Cc1cc(c2cc(cc(c2n1)F)F)NC(=O)Nc3ccc(cc3)N(C)C

InChI Key InChIKey=JTARFZSNUAGHRB-UHFFFAOYSA-N

Data  9 KI  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50423648   

TargetOrexin/Hypocretin receptor type 1(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50423648(SB-408124 | CHEMBL1334465)
Affinity DataKd:  27nMAssay Description:Binding affinity to OX1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOrexin/Hypocretin receptor type 1(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50423648(SB-408124 | CHEMBL1334465)
Affinity DataKi:  19nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOrexin/Hypocretin receptor type 1(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50423648(SB-408124 | CHEMBL1334465)
Affinity DataKi:  22nMAssay Description:Binding affinity to orexin receptor 1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOrexin/Hypocretin receptor type 1(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50423648(SB-408124 | CHEMBL1334465)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOrexin receptor type 2(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50423648(SB-408124 | CHEMBL1334465)
Affinity DataKi:  794nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50423648(SB-408124 | CHEMBL1334465)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cell membranes by micro-beta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2019
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50423648(SB-408124 | CHEMBL1334465)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cell membranes by micro-beta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2019
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Tsukuba

Curated by ChEMBL
LigandPNGBDBM50423648(SB-408124 | CHEMBL1334465)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cell membranes by micro-beta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2019
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50423648(SB-408124 | CHEMBL1334465)
Affinity DataKi:  1.41E+3nMAssay Description:Binding affinity to orexin receptor 2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50423648(SB-408124 | CHEMBL1334465)
Affinity DataKi:  2.07E+3nMAssay Description:Antagonist activity at human OX2R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2019
Entry Details Article
PubMed