BDBM50073056 4-Bromo-N-[4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-benzenesulfonamide::CHEMBL292759::SB-214111

SMILES COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1

InChI Key InChIKey=OZYPUQNRUYTZDI-UHFFFAOYSA-N

Data  6 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50073056   

TargetCytochrome P450 2D6(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073056(CHEMBL292759 | SB-214111 | 4-Bromo-N-[4-methoxy-3-...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human cytochrome P450 2D6 as bufuralol 1''-hydroxylation (10 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073056(CHEMBL292759 | SB-214111 | 4-Bromo-N-[4-methoxy-3-...)
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of human cytochrome P450 2C19 as S-mephenytoin-4-hydroxylation (100 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073056(CHEMBL292759 | SB-214111 | 4-Bromo-N-[4-methoxy-3-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory potential of human cytochrome P450 2C9 as Tolbutamide methylhydroxylation (100 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073056(CHEMBL292759 | SB-214111 | 4-Bromo-N-[4-methoxy-3-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human cytochrome P450 1A2 activity as caffeine N3 demethylation (500 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073056(CHEMBL292759 | SB-214111 | 4-Bromo-N-[4-methoxy-3-...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human cytochrome P450 3A4 as total cyclosporin oxidation (1 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50073056(CHEMBL292759 | SB-214111 | 4-Bromo-N-[4-methoxy-3-...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant 5HT6 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50073056(CHEMBL292759 | SB-214111 | 4-Bromo-N-[4-methoxy-3-...)
Affinity DataKi:  2.82nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Rat)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM50073056(CHEMBL292759 | SB-214111 | 4-Bromo-N-[4-methoxy-3-...)
Affinity DataKi:  4.79nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50073056(CHEMBL292759 | SB-214111 | 4-Bromo-N-[4-methoxy-3-...)
Affinity DataKi:  5nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50073056(CHEMBL292759 | SB-214111 | 4-Bromo-N-[4-methoxy-3-...)
Affinity DataKi:  5nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Universidad Complutense De Madrid

Curated by ChEMBL
LigandPNGBDBM50073056(CHEMBL292759 | SB-214111 | 4-Bromo-N-[4-methoxy-3-...)
Affinity DataKi:  5nMAssay Description:Binding affinity against 5 Hydroxy tryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Mouse)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM50073056(CHEMBL292759 | SB-214111 | 4-Bromo-N-[4-methoxy-3-...)
Affinity DataKi:  22.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed