BDBM50044784 CHEBI:79090::SB-202190::US10865384, Compound SB202190
SMILES Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccncc1)-c1ccc(F)cc1
InChI Key InChIKey=QHKYPYXTTXKZST-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 36 hits for monomerid = 50044784
Affinity DataIC50: 11nMAssay Description:Binding affinity to P38alpha MAPK (unknown origin) using Smad3 as substrate incubated for 1 hr in presence of ATP by ELISA based competitive binding ...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction in melanin synthesis after 2 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction in melanin synthesis after 2 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter p38 MAP kinase binding assay from D...More data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter p38 MAP kinase binding assay from D...More data for this Ligand-Target Pair
Affinity DataIC50: 83nMAssay Description:Table 2: The p38 MAPK IC50 values of selected compounds except IM-32 to IM-44 were determined using the HitHunter p38 MAP kinase binding assay from D...More data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Table 3: Small molecules were tested for their inhibitory activities towards casein kinase 1 delta (CK1δ) and 1 epsilon (CK1ϵ). The in vit...More data for this Ligand-Target Pair
Affinity DataIC50: 83nMAssay Description:Table 3: Small molecules were tested for their inhibitory activities towards casein kinase 1 delta (CK1δ) and 1 epsilon (CK1ϵ). The in vit...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of p38 alpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of human p38alpha using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Binding affinity to recombinant human N-terminal GST-tagged P38alpha MAPK expressed in Escherichia coli using ERKtide as substrate by mobility shift ...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of p38alpha (unknown origin) incubated for 20 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
TargetBromodomain testis-specific protein(Human)
University of Modena and Reggio Emilia
Curated by ChEMBL
University of Modena and Reggio Emilia
Curated by ChEMBL
Affinity DataKd: 3.42E+3nMAssay Description:Binding affinity to human N-terminal His6-tagged BRDTexpressed in Escherichia coli BL21 (DE3) cells (21 to 137 residues) incubated for 1 hrMore data for this Ligand-Target Pair
TargetBromodomain testis-specific protein(Human)
University of Modena and Reggio Emilia
Curated by ChEMBL
University of Modena and Reggio Emilia
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human N-terminal His6-tagged BRDT (21 to 137 residues) expressed in Escherichia coli BL21 (DE3) cells incubated for 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of P38alphaMAPK (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11(Human)
University of Modena and Reggio Emilia
Curated by ChEMBL
University of Modena and Reggio Emilia
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of P38betaMAPK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human N-terminal His6-tagged BRD4 (44 to 168 residues) by alpha screen assayMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of p38alpha/beta (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11(Human)
University of Modena and Reggio Emilia
Curated by ChEMBL
University of Modena and Reggio Emilia
Curated by ChEMBL
Affinity DataIC50: 9.80nMAssay Description:Inhibition of p38beta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of JAK1 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of JAK2 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of JAK3 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of p38alpha MAPK (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.70nMAssay Description:Inhibition of P38a/MAPK14 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Binding affinity towards human Mitogen-activated protein kinase p38 expressed as IC50More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
TargetBromodomain testis-specific protein(Human)
University of Modena and Reggio Emilia
Curated by ChEMBL
University of Modena and Reggio Emilia
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human His6-TEV protease-tagged BRDT bromodomain 1 expressed in bacteria using H-YSGRGKacGGKacGLGKacGGAKacRHRK-(Biotin)-OH a...More data for this Ligand-Target Pair
Affinity DataIC50: 188nMAssay Description:Inhibition of CK1-delta (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of recombinant human His6-TEV protease-tagged BRD4 bromodomain 1 expressed in bacteria using H-YSGRGKacGGKacGLGKacGGAKacRHRK-(Biotin)-OH a...More data for this Ligand-Target Pair
Affinity DataKd: 3.40E+3nMAssay Description:Binding affinity to recombinant human His6-TEV protease-tagged BRD4 bromodomain 1 expressed in bacteria by isothermal titration calorimetric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged BRD4 expressed in Escherichia coli BL21(DE3) cells using biotinylated histone H4 peptide as su...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/14(Human)
University of Texas Medical Branch
Curated by ChEMBL
University of Texas Medical Branch
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of p38alpha/beta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of MAPK14 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 9.34E+3nMAssay Description:Inhibition of human TTBK2 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.72E+4nMAssay Description:Inhibition of human TTBK1 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11(Human)
University of Modena and Reggio Emilia
Curated by ChEMBL
University of Modena and Reggio Emilia
Curated by ChEMBL
Affinity DataIC50: 33.1nMAssay Description:Inhibition of human p38beta using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair