BDBM50128690 4-Hydroxy-7-{2-[2-(3-phenethyloxy-propane-1-sulfonyl)-ethylamino]-ethyl}-3H-benzothiazol-2-one::CHEMBL82663::SB-07499

SMILES Oc1ccc(CCNCCS(=O)(=O)CCCOCCc2ccccc2)c2sc(=O)[nH]c12

InChI Key InChIKey=DBCKRBGYGMVSTI-UHFFFAOYSA-N

Data  2 KI  5 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50128690   

TargetBeta-2 adrenergic receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50128690(SB-07499 | 4-Hydroxy-7-{2-[2-(3-phenethyloxy-propa...)
Affinity DataEC50:  0.631nMAssay Description:Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50128690(SB-07499 | 4-Hydroxy-7-{2-[2-(3-phenethyloxy-propa...)
Affinity DataEC50:  0.631nMAssay Description:Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128690(SB-07499 | 4-Hydroxy-7-{2-[2-(3-phenethyloxy-propa...)
Affinity DataIC50: 38nMAssay Description:In vitro inhibitory activity was determined against human Phosphodiesterase 4 isoform using a construct representing the common region of spliced var...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50128690(SB-07499 | 4-Hydroxy-7-{2-[2-(3-phenethyloxy-propa...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to beta1 adrenoceptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50128690(SB-07499 | 4-Hydroxy-7-{2-[2-(3-phenethyloxy-propa...)
Affinity DataIC50: 100nMAssay Description:Binding affinity to dopamine 2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50128690(SB-07499 | 4-Hydroxy-7-{2-[2-(3-phenethyloxy-propa...)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to adrenergic beta1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50128690(SB-07499 | 4-Hydroxy-7-{2-[2-(3-phenethyloxy-propa...)
Affinity DataEC50:  4.5nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as increase in GTPgamma35S binding by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50128690(SB-07499 | 4-Hydroxy-7-{2-[2-(3-phenethyloxy-propa...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50128690(SB-07499 | 4-Hydroxy-7-{2-[2-(3-phenethyloxy-propa...)
Affinity DataKi:  4nMAssay Description:Binding affinity to human beta2-adrenoceptor by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50128690(SB-07499 | 4-Hydroxy-7-{2-[2-(3-phenethyloxy-propa...)
Affinity DataKi:  3.92E+3nMAssay Description:Binding affinity to human beta1-adrenoceptor by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed