BDBM50189885 Rohitukine

SMILES CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(C)cc2=O

InChI Key InChIKey=MOCVYVBNJQIVOV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50189885   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
India Academy of Scientific & Innovative Research (Acsir)

Curated by ChEMBL
LigandPNGBDBM50189885(Rohitukine)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of human Cdk2/cyclin A using histone H1 substrate after 30 mins by 33P-ATP filter-binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2017
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
India Academy of Scientific & Innovative Research (Acsir)

Curated by ChEMBL
LigandPNGBDBM50189885(Rohitukine)
Affinity DataIC50: 300nMAssay Description:Inhibition of human Cdk9/T1 using YSPTSPSYSPTSPSYSPTSPKKK peptide as substrate after 30 mins by 33P-ATP filter-binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2017
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
India Academy of Scientific & Innovative Research (Acsir)

Curated by ChEMBL
LigandPNGBDBM50189885(Rohitukine)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) using histone H1 as substrate after 30 mins in presence of [33P]-gamma-ATP by filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
India Academy of Scientific & Innovative Research (Acsir)

Curated by ChEMBL
LigandPNGBDBM50189885(Rohitukine)
Affinity DataIC50: 300nMAssay Description:Inhibition of CDK9/cyclin T1 (unknown origin) using YSPTSPSYSPTSPSYSPTSPKKK as substrate after 30 mins in presence of [33P]-gamma-ATP by filter bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
India Academy of Scientific & Innovative Research (Acsir)

Curated by ChEMBL
LigandPNGBDBM50189885(Rohitukine)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) using AAKAKKTPKKAKK-CONH2 as substrate after 20 mins by immunoprecipitation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
India Academy of Scientific & Innovative Research (Acsir)

Curated by ChEMBL
LigandPNGBDBM50189885(Rohitukine)
Affinity DataIC50: 300nMAssay Description:Inhibition of CDK9/cyclin T (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed