BDBM50063994 CHEMBL338404::Ro-166491

SMILES NCCNC(=O)c1ccc(Cl)cc1

InChI Key InChIKey=AIHKMGLJGLKLSI-UHFFFAOYSA-N

Data  2 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50063994   

TargetAmine oxidase [flavin-containing] B(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50063994(CHEMBL338404 | Ro-166491)
Affinity DataEC50:  2.90E+4nMAssay Description:Inhibition of human recombinant soluble MAO-B assessed as thermal shift after 20 mins by SYPRO orange staining-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Rat)
Hainan Normal University

Curated by ChEMBL
LigandPNGBDBM50063994(CHEMBL338404 | Ro-166491)
Affinity DataIC50: 1.40E+6nMAssay Description:Inhibition of rat MAOB using benzylamine as substrate pretreated for 1200 secs followed by substrate addition and measured after 3600 secsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Rat)
Hainan Normal University

Curated by ChEMBL
LigandPNGBDBM50063994(CHEMBL338404 | Ro-166491)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of rat MAOA using 5-hydroxytryptamine as substrate pretreated for 1200 secs followed by substrate addition and measured after 3600 secsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50063994(CHEMBL338404 | Ro-166491)
Affinity DataKi:  32nMAssay Description:Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50063994(CHEMBL338404 | Ro-166491)
Affinity DataKi:  997nMAssay Description:Inhibition of human recombinant microsomal MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed