BDBM50546439 Balovaptan::RG-7314::RO-5285119::RO5285119::Rg7314

SMILES CN1Cc2nnc([C@H]3CC[C@@H](CC3)Oc3ccccn3)n2-c2ccc(Cl)cc2C1

InChI Key InChIKey=GMPZPHGHNDMRKL-UHFFFAOYSA-N

Data  6 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50546439   

TargetVasopressin V1a receptor(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50546439(Balovaptan | Rg7314 | RG-7314 | RO-5285119 | RO528...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50546439(Balovaptan | Rg7314 | RG-7314 | RO-5285119 | RO528...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50546439(Balovaptan | Rg7314 | RG-7314 | RO-5285119 | RO528...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50546439(Balovaptan | Rg7314 | RG-7314 | RO-5285119 | RO528...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50546439(Balovaptan | Rg7314 | RG-7314 | RO-5285119 | RO528...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50546439(Balovaptan | Rg7314 | RG-7314 | RO-5285119 | RO528...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50546439(Balovaptan | Rg7314 | RG-7314 | RO-5285119 | RO528...)
Affinity DataKi:  0.700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetVasopressin V2 receptor(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50546439(Balovaptan | Rg7314 | RG-7314 | RO-5285119 | RO528...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]-arginine-vasopressin from human V2 receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetVasopressin V2 receptor(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50546439(Balovaptan | Rg7314 | RG-7314 | RO-5285119 | RO528...)
Affinity DataKi:  1.60E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed