BDBM50127398 8-Methyl-2-phenyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane::CHEMBL51771::RTI-422

SMILES CN1[C@@H]2CCC1C([C@H](C2)c1ccc(C)cc1)c1ccccc1

InChI Key

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50127398   

TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127398(RTI-422 | 8-Methyl-2-phenyl-3-p-tolyl-8-aza-bicycl...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of [3H]paroxetine binding at serotonin transporter was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127398(RTI-422 | 8-Methyl-2-phenyl-3-p-tolyl-8-aza-bicycl...)
Affinity DataIC50: 2nMAssay Description:Inhibition of [3H]WIN-35428 binding at dopamine transporter was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127398(RTI-422 | 8-Methyl-2-phenyl-3-p-tolyl-8-aza-bicycl...)
Affinity DataIC50: 480nMAssay Description:Inhibition of [3H]nisoxetine binding at norepinephrine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127398(RTI-422 | 8-Methyl-2-phenyl-3-p-tolyl-8-aza-bicycl...)
Affinity DataKi:  289nMAssay Description:Affinity for norepinephrine transporter determined by [3H]nisoxetine displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127398(RTI-422 | 8-Methyl-2-phenyl-3-p-tolyl-8-aza-bicycl...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of [3H]paroxetine binding at serotonin transporter was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed