BDBM50127383 3-(4-Chloro-phenyl)-8-methyl-2-(3-phenyl-isoxazol-5-yl)-8-aza-bicyclo[3.2.1]octane::CHEMBL298580::RTI-177

SMILES CN1[C@@H]2CCC1C([C@H](C2)c1ccc(Cl)cc1)c1cc(no1)-c1ccccc1

InChI Key

Data  4 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50127383   

TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127383(RTI-177 | 3-(4-Chloro-phenyl)-8-methyl-2-(3-phenyl...)
Affinity DataIC50: 2.42E+3nMAssay Description:Inhibition of [3H]paroxetine binding at serotonin transporter was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127383(RTI-177 | 3-(4-Chloro-phenyl)-8-methyl-2-(3-phenyl...)
Affinity DataIC50: 1.30nMAssay Description:Binding affinity towards dopamine transporter was determined using DA[3H]WIN-35428 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127383(RTI-177 | 3-(4-Chloro-phenyl)-8-methyl-2-(3-phenyl...)
Affinity DataIC50: 2.42E+3nMAssay Description:Binding affinity towards Serotonin transporter was determined using 5-HT [3H]paroxetine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127383(RTI-177 | 3-(4-Chloro-phenyl)-8-methyl-2-(3-phenyl...)
Affinity DataIC50: 504nMAssay Description:Binding affinity towards Norepinephrine transporter was determined using NE[3H]Nisoxetine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127383(RTI-177 | 3-(4-Chloro-phenyl)-8-methyl-2-(3-phenyl...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of [3H]WIN-35428 binding at dopamine transporter was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127383(RTI-177 | 3-(4-Chloro-phenyl)-8-methyl-2-(3-phenyl...)
Affinity DataIC50: 504nMAssay Description:Inhibition of [3H]nisoxetine binding at norepinephrine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127383(RTI-177 | 3-(4-Chloro-phenyl)-8-methyl-2-(3-phenyl...)
Affinity DataIC50: 2.42E+3nMAssay Description:Inhibition of norepinephrine transporter (NET) determined using [3H]nisoxetine radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127383(RTI-177 | 3-(4-Chloro-phenyl)-8-methyl-2-(3-phenyl...)
Affinity DataIC50: 1.28nMAssay Description:Inhibitory concentration required to inhibit dopamine transporter DAT was determined by using [3H]WIN-35428 radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127383(RTI-177 | 3-(4-Chloro-phenyl)-8-methyl-2-(3-phenyl...)
Affinity DataIC50: 504nMAssay Description:Inhibitory concentration required to inhibit serotonin transporter 5-HTT was determined by using [3H]paroxetine radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127383(RTI-177 | 3-(4-Chloro-phenyl)-8-methyl-2-(3-phenyl...)
Affinity DataKi:  220nMAssay Description:Inhibition of [3H]paroxetine binding at serotonin transporter was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127383(RTI-177 | 3-(4-Chloro-phenyl)-8-methyl-2-(3-phenyl...)
Affinity DataKi:  220nMAssay Description:Binding affinity towards norepinephrine transporter was determined using [3H]nisoxetine radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127383(RTI-177 | 3-(4-Chloro-phenyl)-8-methyl-2-(3-phenyl...)
Affinity DataKi:  304nMAssay Description:Affinity for norepinephrine transporter determined by [3H]nisoxetine displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50127383(RTI-177 | 3-(4-Chloro-phenyl)-8-methyl-2-(3-phenyl...)
Affinity DataKi:  305nMAssay Description:Binding affinity towards serotonin transporter 5-HTT was determined using [3H]paroxetine radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed