BDBM50249134 4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2-amine::CHEMBL473186::RS-127445

SMILES CC(C)c1cc(nc(N)n1)-c1ccc(F)c2ccccc12

InChI Key InChIKey=ZZZQXCUPAJFVBN-UHFFFAOYSA-N

Data  11 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50249134   

Target5-hydroxytryptamine receptor 2B(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249134(RS-127445 | CHEMBL473186 | 4-(4-fluoronaphthalen-1...)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin lumin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249134(RS-127445 | CHEMBL473186 | 4-(4-fluoronaphthalen-1...)
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin lumin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249134(RS-127445 | CHEMBL473186 | 4-(4-fluoronaphthalen-1...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to 5-HT2B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
City University of New York

Curated by ChEMBL
LigandPNGBDBM50249134(RS-127445 | CHEMBL473186 | 4-(4-fluoronaphthalen-1...)
Affinity DataKi:  0.316nMAssay Description:Binding affinity to 5HT1B receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249134(RS-127445 | CHEMBL473186 | 4-(4-fluoronaphthalen-1...)
Affinity DataKi:  0.320nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50249134(RS-127445 | CHEMBL473186 | 4-(4-fluoronaphthalen-1...)
Affinity DataKi:  1.07nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50249134(RS-127445 | CHEMBL473186 | 4-(4-fluoronaphthalen-1...)
Affinity DataKi:  398nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50249134(RS-127445 | CHEMBL473186 | 4-(4-fluoronaphthalen-1...)
Affinity DataKi:  468nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50249134(RS-127445 | CHEMBL473186 | 4-(4-fluoronaphthalen-1...)
Affinity DataKi:  501nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50249134(RS-127445 | CHEMBL473186 | 4-(4-fluoronaphthalen-1...)
Affinity DataKi:  933nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50249134(RS-127445 | CHEMBL473186 | 4-(4-fluoronaphthalen-1...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 5A(Human)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50249134(RS-127445 | CHEMBL473186 | 4-(4-fluoronaphthalen-1...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50249134(RS-127445 | CHEMBL473186 | 4-(4-fluoronaphthalen-1...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2012
Entry Details Article
PubMed