BDBM50160152 3-(3-{3-[4-Fluoro-2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperazin-1-yl}-propyl)-5-methyl-1H-pyrimidine-2,4-dione::3-(3-{4-[4-Fluoro-2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperazin-1-yl}-propyl)-5-methyl-1H-pyrimidine-2,4-dione::CHEMBL24777::RS-100975::Ro-700004

SMILES Cc1c[nH]c(=O)n(CCCN2CCN(CC2)c2ccc(F)cc2OCC(F)(F)F)c1=O

InChI Key InChIKey=WEZFJPKJUIGDPS-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50160152   

TargetAlpha-1A adrenergic receptor(Human)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM50160152(CHEMBL24777 | 3-(3-{4-[4-Fluoro-2-(2,2,2-trifluoro...)
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM50160152(CHEMBL24777 | 3-(3-{4-[4-Fluoro-2-(2,2,2-trifluoro...)
Affinity DataKi:  1.30nMAssay Description:Binding constant measured against Alpha-1A adrenergic receptor in human prostate; ++:moderately activeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM50160152(CHEMBL24777 | 3-(3-{4-[4-Fluoro-2-(2,2,2-trifluoro...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2018
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
Roche Bioscience

Curated by ChEMBL
LigandPNGBDBM50160152(CHEMBL24777 | 3-(3-{4-[4-Fluoro-2-(2,2,2-trifluoro...)
Affinity DataKi:  63nMAssay Description:Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1D adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2018
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Mouse)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM50160152(CHEMBL24777 | 3-(3-{4-[4-Fluoro-2-(2,2,2-trifluoro...)
Affinity DataKi:  79nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Roche Bioscience

Curated by ChEMBL
LigandPNGBDBM50160152(CHEMBL24777 | 3-(3-{4-[4-Fluoro-2-(2,2,2-trifluoro...)
Affinity DataKi:  79nMAssay Description:Inhibition of [3H]prazosin binding to CHO-K1 whole cells expressing human cloned Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2018
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
University of Dublin

Curated by PDSP Ki Database
LigandPNGBDBM50160152(CHEMBL24777 | 3-(3-{4-[4-Fluoro-2-(2,2,2-trifluoro...)
Affinity DataKi:  100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed