BDBM84950 CAS_183782::NSC_183782::RS 67333

SMILES CCCCN1CCC(CCC(=O)c2cc(Cl)c(N)cc2OC)CC1

InChI Key InChIKey=JBHLYIVFFLNISJ-UHFFFAOYSA-N

Data  19 KI  2 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 84950   

Target5-hydroxytryptamine receptor 4(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataEC50:  2nMAssay Description:Partial agonist activity at human 5HT4E receptor expressed in CHO cells assessed as cAMP accumulation incubated for 4 hrs by luciferase reporter gene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human 5HT4e receptor expressed in CHO cells assessed as cAMP level after 4 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataEC50:  8.70nMAssay Description:Agonist activity at 5-HT4 receptor in Sprague-Dawley rat oesophagus assessed as relaxation of carbachol precontracted oesophagusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataIC50: 403nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured every 1 min for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataIC50: 403nMAssay Description:Inhibition of human erythrocyte AChE pre-incubated for 5 mins before acetylthiocholine iodide substrate by Ellman' methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2016
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataKi:  1.25nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataKi:  1.99nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataKi:  9.30nMAssay Description:Displacement of [3H]-GR113808 from recombinant human 5-HT4BR expressed in membranes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataKi:  9.30nMAssay Description:Displacement of [3H]GR113808 from 5-HT4R in guinea pig brain membranes incubated for 30 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2016
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataKi:  200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Rat)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataKi:  398nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataKi:  501nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataKi:  794nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Rat)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataKi:  1.26E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataKi:  1.26E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataKi:  5.01E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataKi:  6.31E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Pig)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rhesus macaque)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Rat)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Rat)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Rat)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor [16-465](Rat)
Syntex Discovery Research

Curated by PDSP Ki Database
LigandPNGBDBM84950(CAS_183782 | NSC_183782 | RS 67333)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed