BDBM50020680 4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one::CHEMBL589::ROPINIROLE

SMILES CCCN(CCC)CCc1cccc2NC(=O)Cc12

InChI Key InChIKey=UHSKFQJFRQCDBE-UHFFFAOYSA-N

Data  53 KI  3 IC50  17 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 73 hits for monomerid = 50020680   

TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataEC50:  304nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataEC50:  304nMAssay Description:Agonist activity at human dopamine D2L receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataIC50: 6.81E+3nMAssay Description:Displacement of [3H]spiroperidol from homogenized bovine pituitary Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataEC50:  302nMAssay Description:Agonist activity at human dopamine D2L receptor expressed in CHO cell membranes incubated for 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataEC50:  83nMAssay Description:Agonist activity at human recombinant dopamine D2 receptor expressed in rat pituitary cells assessed as inhibition of forskolin-stimulated cAMP accum...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataEC50:  304nMAssay Description:Agonist activity at human dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataEC50:  19.2nMAssay Description:Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataEC50:  304nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataEC50:  10.3nMAssay Description:Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataEC50:  10.3nMAssay Description:Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataEC50:  100nMAssay Description:Inhibitory activity against constrictor response to electrical stimulation in the isolated perfused rabbit ear artery(REA) expressing dopamine recept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2018
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataEC50:  89nMAssay Description:Partial agonist activity at human D2SR expressed in HEK293T cells co-expressing (EA)beta-arrestin2 assessed as induction of beta-arrestin2 recruitmen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details Article
PubMed
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataEC50:  76nMAssay Description:Agonist activity at Rattus norvegicus (rat) dopamine D2 receptor transfected in african green monkey COS7 cells assessed as inhibition of forskolin-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataIC50: 107nMAssay Description:Displacement of [3H]nemonapride from Rattus norvegicus (rat) wild type dopamine D3 receptor transfected in african green monkey COS7 cells after 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataIC50: 1.80E+3nMAssay Description:Displacement of [3H]nemonapride from Rattus norvegicus (rat) wild type dopamine D2 receptor transfected in african green monkey COS7 cells after 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataEC50:  330nMAssay Description:Agonist activity at human D2SR expressed in HEK293 cell membranes co-expressing PTX insensitive variant of Galphao1 incubated for 30 mins by [35S]GTP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataEC50:  89nMAssay Description:Agonist activity at human D2SR expressed in HEK293 cells incubated for 5 hrs by beta-Arrestin 2 recruitment assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataEC50:  330nMAssay Description:Agonist activity at human D2S receptor expressed in HEK293T cell membranes coexpressing Galphao1 assessed as induction of nucleotide exchange preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataEC50:  30nMAssay Description:Partial agonist activity at human D2SR expressed in HEK293T cells co-expressing (EA)beta-arrestin2 and GRK2 assessed as induction of beta-arrestin2 r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  7.20nMAssay Description:Binding affinity towards Dopamine receptor D2 by displacement of [3H]U-86170.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  19nMAssay Description:Binding affinity towards Dopamine receptor D3 by displacement of [3H](+)-7-OH-DPAT.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  29.3nMAssay Description:Displacement of [3H]spiperone from rat D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  36.3nMAssay Description:Displacement of [3H]spiperone form human cloned dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  37.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  37.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  288nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  676nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  676nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  692nMAssay Description:Displacement of [3H]spiperone form human cloned dopamine D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  759nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  759nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  851nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  851nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  873nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  933nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  933nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  1.15E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  1.20E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  1.20E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  1.38E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  1.38E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  1.51E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  1.71E+3nMAssay Description:Binding affinity towards Serotonin 5-hydroxytryptamine 1A receptor by displacement of [3H]-(+)-8-OH-DPAT.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  1.86E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  1.86E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  2.67E+3nMAssay Description:Displacement of [3H]spiperone from rat D2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  2.95E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  3.80E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Institut De Recherches Servier

Curated by PDSP Ki Database
LigandPNGBDBM50020680(CHEMBL589 | 4-[2-(dipropylamino)ethyl]-1,3-dihydro...)
Affinity DataKi:  3.80E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
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