BDBM50581319 BIM-22493::RM-493::SETMELANOTIDE::Setmelanotide

SMILES C[C@H]1NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O

InChI Key InChIKey=HDHDTKMUACZDAA-UHFFFAOYSA-N

Data  6 KI  2 IC50  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50581319   

TargetMelanocortin receptor 3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50581319(Setmelanotide | BIM-22493 | RM-493 | SETMELANOTIDE)
Affinity DataEC50:  0.151nMAssay Description:Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50581319(Setmelanotide | BIM-22493 | RM-493 | SETMELANOTIDE)
Affinity DataEC50:  0.280nMAssay Description:Inhibition of rat MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50581319(Setmelanotide | BIM-22493 | RM-493 | SETMELANOTIDE)
Affinity DataEC50:  0.270nMAssay Description:Inhibition of human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMelanocortin receptor 5(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50581319(Setmelanotide | BIM-22493 | RM-493 | SETMELANOTIDE)
Affinity DataIC50: 1.86E+3nMAssay Description:Agonist activity at human MC5R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50581319(Setmelanotide | BIM-22493 | RM-493 | SETMELANOTIDE)
Affinity DataEC50:  0.398nMAssay Description:Antagonist activity at human MC4R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMelanocortin receptor 3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50581319(Setmelanotide | BIM-22493 | RM-493 | SETMELANOTIDE)
Affinity DataEC50:  0.151nMAssay Description:Agonist activity at human MC3R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50581319(Setmelanotide | BIM-22493 | RM-493 | SETMELANOTIDE)
Affinity DataEC50:  0.158nMAssay Description:Agonist activity at human MC1R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMelanocortin receptor 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50581319(Setmelanotide | BIM-22493 | RM-493 | SETMELANOTIDE)
Affinity DataEC50: >0.0501nMAssay Description:Agonist activity at human melanocortin receptor 4 expressed in human T-REx-293 cells using high doxycycline assessed as stimulation of intracellular ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50581319(Setmelanotide | BIM-22493 | RM-493 | SETMELANOTIDE)
Affinity DataIC50: 1.91E+3nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC5R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50581319(Setmelanotide | BIM-22493 | RM-493 | SETMELANOTIDE)
Affinity DataEC50:  0.389nMAssay Description:Agonist activity at human melanocortin receptor 4 expressed in human T-REx-293 cells using low doxycycline assessed as stimulation of intracellular c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50581319(Setmelanotide | BIM-22493 | RM-493 | SETMELANOTIDE)
Affinity DataEC50:  0.158nMAssay Description:Agonist activity at human melanocortin receptor 1 expressed in human T-Rex-293 cells assessed as stimulation of intracellular cAMP accumulation incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50581319(Setmelanotide | BIM-22493 | RM-493 | SETMELANOTIDE)
Affinity DataKi:  4.10nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50581319(Setmelanotide | BIM-22493 | RM-493 | SETMELANOTIDE)
Affinity DataKi:  4.30nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50581319(Setmelanotide | BIM-22493 | RM-493 | SETMELANOTIDE)
Affinity DataKi:  4.60nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMelanocyte-stimulating hormone receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50581319(Setmelanotide | BIM-22493 | RM-493 | SETMELANOTIDE)
Affinity DataKi:  4.60nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50581319(Setmelanotide | BIM-22493 | RM-493 | SETMELANOTIDE)
Affinity DataKi:  13nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16 to 23 hrs by 1450 microbeta trilux scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMelanocortin receptor 3(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50581319(Setmelanotide | BIM-22493 | RM-493 | SETMELANOTIDE)
Affinity DataKi:  13nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK2936E cell membrane measured after 16-23 hrs by 1450 microbeta trilux scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed