BDBM50452674 RG-1577::Sembragiline

SMILES CC(=O)N[C@@H]1CN(C(=O)C1)c1ccc(OCc2cccc(F)c2)cc1

InChI Key InChIKey=VMAVCCUQTALHOB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50452674   

TargetAmine oxidase [flavin-containing] B(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50452674(RG-1577 | Sembragiline)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human MAO-B using benzylamine as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Ntz Lab

Curated by ChEMBL
LigandPNGBDBM50452674(RG-1577 | Sembragiline)
Affinity DataIC50: 3.85E+3nMAssay Description:Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect cells using p-tyramine as substrate preincubated for 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Rat)
Ntz Lab

Curated by ChEMBL
LigandPNGBDBM50452674(RG-1577 | Sembragiline)
Affinity DataIC50: 15nMAssay Description:Inhibition of Sprague-Dawley rat liver MAO-B using p-tyramine as substrate preincubated for 15 mins and measured after 45 mins by resorufin-based flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Yonsei University

Curated by ChEMBL
LigandPNGBDBM50452674(RG-1577 | Sembragiline)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 insect cells using p-tyramine as substrate preincubated for 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Rat)
Ntz Lab

Curated by ChEMBL
LigandPNGBDBM50452674(RG-1577 | Sembragiline)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of Sprague-Dawley rat liver MAO-A using p-tyramine as substrate preincubated for 15 mins and measured after 45 mins by resorufin-based flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed