BDBM22904 (2R)-1-(1H-imidazol-5-yl)propan-2-amine::(R)-alpha-Methylhistamine::Alpha-Methylhistamine-R::Alpha-Methylhistane-R::CHEMBL268229::R-alpha-methylhistamine::RAMH

SMILES C[C@@H](N)Cc1cnc[nH]1

InChI Key InChIKey=XNQIOISZPFVUFG-UHFFFAOYSA-N

Data  33 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 35 hits for monomerid = 22904   

TargetHistamine H3 receptor(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of rat histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataEC50:  2.80nMAssay Description:Agonist activity at human recombinant histamine H3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetHistamine receptor H4(Guinea pig)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  0.150nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2012
Entry Details Article
PubMed
TargetHistamine receptor H4(Guinea pig)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  0.150nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2012
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
U. 109

Curated by PDSP Ki Database
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  0.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
TargetHrh3 protein(Rat)
U. 109

Curated by PDSP Ki Database
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  0.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  0.550nMAssay Description:Displacement of [3H[N-alpha-methylhistamine form human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to the human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  0.700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  0.880nMAssay Description:Inhibition of Histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
U. 109

Curated by PDSP Ki Database
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
U. 109

Curated by PDSP Ki Database
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  1.25nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
U. 109

Curated by PDSP Ki Database
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  1.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
TargetHistamine H3 receptor(Guinea pig)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity against Histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity of compound towards Histamine H3 receptor was determined in guinea pig brain tissue using [3H]- N alpha-methylhistamine radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
U. 109

Curated by PDSP Ki Database
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  1.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
TargetHistamine H3 receptor(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  2.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
TargetHistamine H3 receptor(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  2.70nMAssay Description:Antagonist potency against human histamine H3 receptor expressed in CHO cells was determined by GTPgamma-S-assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
U. 109

Curated by PDSP Ki Database
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  3.98nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
U. 109

Curated by PDSP Ki Database
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
TargetHistamine H3 receptor(Human)
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  6nMAssay Description:Ligand displacement assays were performed on The SK-N-MC/hH3R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
U. 109

Curated by PDSP Ki Database
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  9.12nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details
PubMed
TargetHrh3 protein(Rat)
U. 109

Curated by PDSP Ki Database
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  25.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  146nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  146nMAssay Description:Binding affinity to the human histamine H4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  184nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  232nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  251nMAssay Description:Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2008
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
The R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  348nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  813nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetHrh3 protein(Rat)
U. 109

Curated by PDSP Ki Database
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi:  1.06E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to H-1 receptor was determined in guinea pig brain tissue using [3H]- N alpha-methylhistamine ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM22904(CHEMBL268229 | Alpha-Methylhistane-R | (2R)-1-(1H-...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity against H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed