BDBM50533006 Af-219::Gefapixant::R-1646::R1646::RG-1646::RG1646::RO-4926219::RO4926219::US20240034729, Positive compound 2

SMILES CC(C)c1cc(c(cc1Oc2cnc(nc2N)N)S(=O)(=O)N)OC

InChI Key InChIKey=HLWURFKMDLAKOD-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50533006   

TargetP2X purinoceptor 3(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50533006(Af-219 | Gefapixant | R-1646 | R1646 | RG-1646 | R...)
Affinity DataIC50: 45nMAssay Description:Antagonist activity at human recombinant P2X3 receptor expressed in HEK293-Tet-on cells assessed as alpha,beta-methylene-ATP-stimulated Ca2+ influx b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2X purinoceptor 3(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50533006(Af-219 | Gefapixant | R-1646 | R1646 | RG-1646 | R...)
Affinity DataIC50: 45nMAssay Description:Antagonist activity at human recombinant P2X3 receptor expressed in HEK293-Tet-on cells assessed as alpha,beta-methylene-ATP-stimulated Ca2+ influx b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2X purinoceptor 3(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50533006(Af-219 | Gefapixant | R-1646 | R1646 | RG-1646 | R...)
Affinity DataIC50: 45nMAssay Description:Antagonist activity at human P2X3R expressed in HEK293 cells assessed as reduction in alphabeta-MeATP-induced intracellular Ca2+ influx pretreated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2X purinoceptor 3(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50533006(Af-219 | Gefapixant | R-1646 | R1646 | RG-1646 | R...)
Affinity DataIC50: 52.2nMAssay Description:The antagonist property of the compounds disclosed herein was determined using the FLIPR (fluorescence imaging plate reader) method, showing that the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)