BDBM50370385 (R)-TIPIFARNIB::R-11577::R-115777::Tipifarnib::Zarnestra

SMILES Cn1cncc1[C@@](N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1

InChI Key InChIKey=PLHJCIYEEKOWNM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50370385   

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50370385(R-11577 | R-115777 | Tipifarnib | Zarnestra | (R)-...)
Affinity DataIC50: 0.860nMAssay Description:Inhibitory concentration against farnesyltransferase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50370385(R-11577 | R-115777 | Tipifarnib | Zarnestra | (R)-...)
Affinity DataIC50: 4.06E+3nMAssay Description:Inhibition of human recombinant CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
LigandPNGBDBM50370385(R-11577 | R-115777 | Tipifarnib | Zarnestra | (R)-...)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of FTase isolated from Kirsten virus-transformed human osteosarcoma cells using K-rasB peptide as substrate in presence of [3H]farnesyl PP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50370385(R-11577 | R-115777 | Tipifarnib | Zarnestra | (R)-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of GGTase1 isolated from Kirsten virus-transformed human osteosarcoma cells using biotin-YRASNRSCAIL peptide as substrate after 120 mins i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50370385(R-11577 | R-115777 | Tipifarnib | Zarnestra | (R)-...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human recombinant FTase using [3H]farnesyldiphosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
LigandPNGBDBM50370385(R-11577 | R-115777 | Tipifarnib | Zarnestra | (R)-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human GGTase1 in human Burkitt lymphoma (Daudi) cell supernatant using [3H]geranylgeranylMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed