BDBM50227829 CHEBI:8455::CHLOROGUANIDE::Proguanil

SMILES [H]/N=C(\Nc1ccc(cc1)Cl)/N/C(=N\[H])/NC(C)C

InChI Key InChIKey=SSOLNOMRVKKSON-UHFFFAOYSA-N

Data  1 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50227829   

TargetTrace amine-associated receptor 1(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50227829(CHEBI:8455 | Proguanil | CHLOROGUANIDE)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human TAAR1 expressed in HEK293 cells assessed as cAMP accumulation after 20 mins by BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2019
Entry Details Article
PubMed
TargetTrace amine-associated receptor 5(Mouse)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50227829(CHEBI:8455 | Proguanil | CHLOROGUANIDE)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mouse TAAR5 expressed in HEK293 cells assessed as cAMP accumulation after 20 mins by BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2019
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Mouse)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50227829(CHEBI:8455 | Proguanil | CHLOROGUANIDE)
Affinity DataEC50:  5.40E+3nMAssay Description:Agonist activity at mouse TAAR1 expressed in HEK293 cells assessed as cAMP accumulation after 20 mins by BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2019
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Federal University of Parana

Curated by ChEMBL
LigandPNGBDBM50227829(CHEBI:8455 | Proguanil | CHLOROGUANIDE)
Affinity DataIC50: 1.18E+5nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in human HEK293 cells membrane vesicles assessed inhibition of BCRP- mediated transport of 3[H]-E1S fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed