BDBM50462013 CHEBI:8241::Piplartine

SMILES COc1cc(cc(c1OC)OC)/C=C/C(=O)N2CCC=CC2=O

InChI Key InChIKey=VABYUUZNAVQNPG-UHFFFAOYSA-N

Data  4 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50462013   

TargetSignal transducer and activator of transcription 3(Human)
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50462013(CHEBI:8241 | Piplartine)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of STAT3 phosphorylation at Tyr705 residues in human DU145 cells after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetThioredoxin reductase 1, cytoplasmic(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50462013(CHEBI:8241 | Piplartine)
Affinity DataIC50: 4.59E+4nMAssay Description:Inhibition of TrxR in human SH-SY5Y cells using DTNB as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetThioredoxin reductase 1, cytoplasmic(Human)
University of Belgrade

Curated by ChEMBL
LigandPNGBDBM50462013(CHEBI:8241 | Piplartine)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of TrxR in human BEL-7402/5-FU cells by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetForkhead box protein O3(Human)
Sorbonne University

Curated by ChEMBL
LigandPNGBDBM50462013(CHEBI:8241 | Piplartine)
Affinity DataEC50:  3.77E+4nMAssay Description:Induction of nuclear translocation of FOXO3 in human U2OS cells by inverted microscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Nantong University

Curated by ChEMBL
LigandPNGBDBM50462013(CHEBI:8241 | Piplartine)
Affinity DataIC50: 1.60E+5nMAssay Description:Inhibition of human recombinant ALR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed