BDBM50014412 Pimasertib::US11147816, Pimasertib (AS703026)::US11701360, Pimasertib

SMILES c1cc(c(cc1I)F)Nc2cnccc2C(=O)NC[C@@H](CO)O

InChI Key InChIKey=VIUAUNHCRHHYNE-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50014412   

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50014412(Pimasertib | US11147816, Pimasertib (AS703026) | U...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of MEK1 in human COLO205 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50014412(Pimasertib | US11147816, Pimasertib (AS703026) | U...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50014412(Pimasertib | US11147816, Pimasertib (AS703026) | U...)
Affinity DataIC50: 1.00E+3nMAssay Description:The IC50 for MEK1 and 2 can be measured by methods in references such as [Yamaguchi et al. (2011) International Journal of Oncology 39:23-31].More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50014412(Pimasertib | US11147816, Pimasertib (AS703026) | U...)
Affinity DataIC50: 1.00E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)