BDBM50026066 1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol::1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-4-(4-chloro-3-trifluoromethyl-phenyl)-piperidin-4-ol::CHEMBL47050::PENFLURIDOL1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-4-(4-chloro-3-trifluoromethyl-phenyl)-piperidin-4-ol::Penfluridol

SMILES c1cc(ccc1C(CCCN2CCC(CC2)(c3ccc(c(c3)C(F)(F)F)Cl)O)c4ccc(cc4)F)F

InChI Key InChIKey=MDLAAYDRRZXJIF-UHFFFAOYSA-N

Data  35 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 38 hits for monomerid = 50026066   

TargetReplicase polyprotein 1ab(2019-nCoV)
Institut Pasteur Korea

LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataIC50: 5.01E+3nMAssay Description:Ten-point DRCs were generated for each drug. Vero cells were seeded at 1.2 × 104 cells per well in DMEM, supplemented with 2% FBS and 1× ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details Article
PubMed
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataIC50: 62nMAssay Description:Inhibition of [3H]spiroperidol (0.5 nM) binding to dopamine receptor from rat striatal membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2018
Entry Details Article
PubMed
TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataEC50:  187nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Bovine)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  5.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Bovine)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  5.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  31nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  63.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
TargetD(1B) dopamine receptor(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  125nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  136nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293T cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  147nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  159nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in stable fibroblast cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  184nMAssay Description:Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  280nMAssay Description:Displacement of [3H]LSD from human 5-HT7A receptor expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  356nMAssay Description:Displacement of [3H]-Way100635 from human 5HT1A receptor expressed in stable CHO cell membranes by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  361nMAssay Description:Displacement of [3H]Ketanserin from 5-HT2A receptor (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  401nMAssay Description:Displacement of [3H]Rauwolscine from human alpha 2B adrenergic receptor expressed in HEK293T cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  445nMAssay Description:Displacement of [3H]Rauwolscine from human alpha 2C adrenergic receptor expressed in MDCK cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Rat)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  515nMAssay Description:Displacement of [3H]CGP12177 from human beta 3 adrenergic receptor expressed in HEK293FlpIN cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  588nMAssay Description:Displacement of [3H]Nisoxetine from human NET expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  602nMAssay Description:Displacement of [3H]Prazosin from human alpha 1D adrenergic receptor expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  867nMAssay Description:Displacement of [3H]DAMGO from human MOR expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  881nMAssay Description:Displacement of [3H]Mesulergine from human 5-HT2C receptor expressed in HEK293FlpIN cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]Cimetidine from human H2 receptor expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 5A(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]LSD from human 5-HT5A receptor expressed in Flp-In CHO cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]Citalopram from human SERT expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D4 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Bovine)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  1.60E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details
PubMed
TargetD(1A) dopamine receptor(Bovine)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  1.60E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  1.71E+3nMAssay Description:Displacement of [3H]DADLE from human DOR expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  1.71E+3nMAssay Description:Displacement of [3H]WIN35428 from human DAT expressed in HEK cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  2.08E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Texas Tech University Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  3.56E+3nMAssay Description:Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  5.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 7(Rat)
Case Western Reserve University

Curated by PDSP Ki Database
LigandPNGBDBM50026066(Penfluridol | PENFLURIDOL1-[4,4-Bis-(4-fluoro-phen...)
Affinity DataKi:  5.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed