BDBM50041296 1-(8-Methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]oct-2-yl)-propan-1-one::CHEMBL23142::PTT(-)

SMILES CCC(=O)C1C2CCC(CC1c1ccc(C)cc1)N2C

InChI Key

Data  9 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50041296   

TargetSodium-dependent dopamine transporter(Rat)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041296(PTT(-) | CHEMBL23142 | 1-(8-Methyl-3-p-tolyl-8-aza...)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of [125I]RTI-55 binding to dopamine transport sites in rat striatal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041296(PTT(-) | CHEMBL23142 | 1-(8-Methyl-3-p-tolyl-8-aza...)
Affinity DataIC50: 8.20nMAssay Description:Displacement of [125I]RTI-55 from dopamine transporter of rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041296(PTT(-) | CHEMBL23142 | 1-(8-Methyl-3-p-tolyl-8-aza...)
Affinity DataIC50: 8.20nMAssay Description:Inhibitory activity in displacing [125I]- RTI-55 binding to dopamine transporter in rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041296(PTT(-) | CHEMBL23142 | 1-(8-Methyl-3-p-tolyl-8-aza...)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of [125I]RTI-55 binding to dopamine transport sites in rat striatal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041296(PTT(-) | CHEMBL23142 | 1-(8-Methyl-3-p-tolyl-8-aza...)
Affinity DataKi:  1.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041296(PTT(-) | CHEMBL23142 | 1-(8-Methyl-3-p-tolyl-8-aza...)
Affinity DataKi:  2.83nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Wake Forest University

Curated by ChEMBL
LigandPNGBDBM50041296(PTT(-) | CHEMBL23142 | 1-(8-Methyl-3-p-tolyl-8-aza...)
Affinity DataKi:  3.45nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details
PubMed
TargetTransporter(Rat)
State University of New York

Curated by ChEMBL
LigandPNGBDBM50041296(PTT(-) | CHEMBL23142 | 1-(8-Methyl-3-p-tolyl-8-aza...)
Affinity DataKi:  65nMAssay Description:Affinity for the displacement of [3H]paroxetine binding to norepinephrine transporter (NET) in rat frontal cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
State University of New York

Curated by ChEMBL
LigandPNGBDBM50041296(PTT(-) | CHEMBL23142 | 1-(8-Methyl-3-p-tolyl-8-aza...)
Affinity DataKi:  130nMAssay Description:Displacement of [3H]paroxetine from Serotonin transporter of rat frontal cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
State University of New York

Curated by ChEMBL
LigandPNGBDBM50041296(PTT(-) | CHEMBL23142 | 1-(8-Methyl-3-p-tolyl-8-aza...)
Affinity DataKi:  131nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transport sites in rat frontal cortex membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
State University of New York

Curated by ChEMBL
LigandPNGBDBM50041296(PTT(-) | CHEMBL23142 | 1-(8-Methyl-3-p-tolyl-8-aza...)
Affinity DataKi:  131nMAssay Description:Affinity for the displacement of [3H]paroxetine binding to serotonin transporter (SERT) in rat frontal cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
State University of New York

Curated by ChEMBL
LigandPNGBDBM50041296(PTT(-) | CHEMBL23142 | 1-(8-Methyl-3-p-tolyl-8-aza...)
Affinity DataKi:  131nMAssay Description:Inhibition of [3H]paroxetine binding to serotonin transport sites in rat frontal cortex membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
State University of New York

Curated by ChEMBL
LigandPNGBDBM50041296(PTT(-) | CHEMBL23142 | 1-(8-Methyl-3-p-tolyl-8-aza...)
Affinity DataKi:  160nMAssay Description:Displacement of [3H]-nisoxatine from Norepinephrine transporter of rat forebrain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed