BDBM23842 2-[2,6-bis(propan-2-yl)phenyl]-3-sulfanylidene-2,3-dihydro-1H-isoindol-1-one::CHEMBL329471::PPS-33

SMILES CC(C)c1cccc(C(C)C)c1N1C(=O)c2ccccc2C1=S

InChI Key InChIKey=NLSLEAPXLGIRCU-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 23842   

TargetAlpha-glucosidase MAL32(Baker's yeast)
University of Tokyo

LigandPNGBDBM23842(2-[2,6-bis(propan-2-yl)phenyl]-3-sulfanylidene-2,3...)
Affinity DataIC50: 8.00E+3nMpH: 7.0 T: 2°CAssay Description:The alpha-glucosidase inhibitory activity of test compounds was determined in a 96-well plate format. The reaction mixture containing enzyme and chro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2008
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
University of Tokyo

LigandPNGBDBM23842(2-[2,6-bis(propan-2-yl)phenyl]-3-sulfanylidene-2,3...)
Affinity DataIC50: 3.10E+3nMT: 2°CAssay Description:Human embryonic kidney (HEK) 293 cells were cultured in D-MEM medium. Transfections were performed by the calcium phosphate coprecipitation method. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2008
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
University of Tokyo

LigandPNGBDBM23842(2-[2,6-bis(propan-2-yl)phenyl]-3-sulfanylidene-2,3...)
Affinity DataIC50: 1.80E+4nMAssay Description:The alpha-glucosidase inhibitory activity of test compounds was determined in a 96-well plate format. The reaction mixture containing enzyme and chro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2008
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM23842(2-[2,6-bis(propan-2-yl)phenyl]-3-sulfanylidene-2,3...)
Affinity DataIC50: 3.09E+5nMAssay Description:Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM23842(2-[2,6-bis(propan-2-yl)phenyl]-3-sulfanylidene-2,3...)
Affinity DataIC50: 5.78E+4nMAssay Description:Inhibitory activity against Dipeptidylpeptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM23842(2-[2,6-bis(propan-2-yl)phenyl]-3-sulfanylidene-2,3...)
Affinity DataIC50: 5.78E+4nMAssay Description:Inhibitory activity against Dipeptidylpeptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2012
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM23842(2-[2,6-bis(propan-2-yl)phenyl]-3-sulfanylidene-2,3...)
Affinity DataIC50: 3.09E+5nMAssay Description:Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2012
Entry Details Article
PubMed