BDBM50161764 (R)-4-chloro-N-(quinuclidin-3-yl)benzamide::(R)-4-chloro-N-(quinuclidin-8-yl)benzamide::CHEMBL177611::N-(R)-1-Aza-bicyclo[2.2.2]oct-3-yl-4-chloro-benzamide::PNU-282987::PNU282987

SMILES Clc1ccc(cc1)C(=O)N[C@H]1CN2CCC1CC2

InChI Key InChIKey=WECKJONDRAUFDD-UHFFFAOYSA-N

Data  10 KI  3 IC50  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50161764   

LigandPNGBDBM50161764(CHEMBL177611 | (R)-4-chloro-N-(quinuclidin-3-yl)be...)
Affinity DataEC50:  40nMpH: 7.4 T: 2°CAssay Description:Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ul of 0.2 mg/ml an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2012
Entry Details

LigandPNGBDBM50161764(CHEMBL177611 | (R)-4-chloro-N-(quinuclidin-3-yl)be...)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of alpha-3-beta-4 nAChR expressed in SHSY5Y cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50161764(CHEMBL177611 | (R)-4-chloro-N-(quinuclidin-3-yl)be...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50161764(CHEMBL177611 | (R)-4-chloro-N-(quinuclidin-3-yl)be...)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of alpha-1-beta-1-gamma-delta nAChR expressed in TE671cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50161764(CHEMBL177611 | (R)-4-chloro-N-(quinuclidin-3-yl)be...)
Affinity DataKd:  3.63E+3nMAssay Description:Binding affinity to Lymnaea stagnalis His6-AChBP expressed in Bac-to-Bac baculovirus expression system by surface plasmon resonance biosensor assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Universite Orleans

Curated by ChEMBL
LigandPNGBDBM50161764(CHEMBL177611 | (R)-4-chloro-N-(quinuclidin-3-yl)be...)
Affinity DataKi:  17nMAssay Description:Displacement of [125I]alpha-bungarotoxin from alpha7 nAchR in rat frontal corticesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Universite Orleans

Curated by ChEMBL
LigandPNGBDBM50161764(CHEMBL177611 | (R)-4-chloro-N-(quinuclidin-3-yl)be...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]MLA from alpha-7 nAChR in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Universite Orleans

Curated by ChEMBL
LigandPNGBDBM50161764(CHEMBL177611 | (R)-4-chloro-N-(quinuclidin-3-yl)be...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]MLA from alpha-7 nACh receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50161764(CHEMBL177611 | (R)-4-chloro-N-(quinuclidin-3-yl)be...)
Affinity DataKi:  24.6nMAssay Description:Displacement of [3H]-MLA from human alpha7 nAChR expressed in human SH-SY5Y cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50161764(CHEMBL177611 | (R)-4-chloro-N-(quinuclidin-3-yl)be...)
Affinity DataKi:  26nMAssay Description:Agonist activity at alpha7 nAChR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50161764(CHEMBL177611 | (R)-4-chloro-N-(quinuclidin-3-yl)be...)
Affinity DataKi:  930nMAssay Description:Inhibition of 5-HT3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2016
Entry Details Article
PubMed
LigandPNGBDBM50161764(CHEMBL177611 | (R)-4-chloro-N-(quinuclidin-3-yl)be...)
Affinity DataKi:  1.66E+3nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholine-binding protein(Great pond snail)
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50161764(CHEMBL177611 | (R)-4-chloro-N-(quinuclidin-3-yl)be...)
Affinity DataKi:  2.09E+3nMAssay Description:Displacement of [3H]epibatidine from Lymnaea stagnalis His6-AChBP expressed in Bac-to-Bac baculovirus expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50161764(CHEMBL177611 | (R)-4-chloro-N-(quinuclidin-3-yl)be...)
Affinity DataKi:  4.54E+3nMAssay Description:Activity at 5HT3 receptor expressed in SHEP1 cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSoluble acetylcholine receptor(California sea hare)
Uc San Diego

LigandPNGBDBM50161764(CHEMBL177611 | (R)-4-chloro-N-(quinuclidin-3-yl)be...)
Affinity DataKi:  3.30E+4nM ΔG°:  -6.01kcal/molepH: 7.4 T: 2°CAssay Description:Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ul of 0.2 mg/ml an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2012
Entry Details