BDBM50308767 1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3]triazolo-[4,5-d]pyrimidin-5-yl)phenyl]-3-{4-[(4-methylpiperazin-1-yl)carbonyl]-phenyl}urea::CHEMBL589258::PKI-402

SMILES CCn1nnc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(cc2)C(=O)N2CCN(C)CC2)cc1)N1CCOCC1

InChI Key InChIKey=ZAXFYGBKZSQBIV-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50308767   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50308767(PKI-402 | 1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3...)
Affinity DataIC50: 2nMAssay Description:Inhibition of PI3K p110alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50308767(PKI-402 | 1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3...)
Affinity DataIC50: 7nMAssay Description:Inhibition of PI3K p110beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50308767(PKI-402 | 1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3...)
Affinity DataIC50: 16nMAssay Description:Inhibition of PI3K p110gamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50308767(PKI-402 | 1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3...)
Affinity DataIC50: 14nMAssay Description:Inhibition of PI3K p110delta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50308767(PKI-402 | 1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3...)
Affinity DataIC50: 3nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50308767(PKI-402 | 1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human PI3Kalpha by fluorescence polarization format assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50308767(PKI-402 | 1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3...)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of human PI3Kgamma by fluorescence polarization format assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50308767(PKI-402 | 1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3...)
Affinity DataIC50: 7nMAssay Description:Inhibition of PI3KbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50308767(PKI-402 | 1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3...)
Affinity DataIC50: 16nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50308767(PKI-402 | 1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of mTOR by DELFIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50308767(PKI-402 | 1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human PI3Kalpha expressed in SF9 insect cells after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50308767(PKI-402 | 1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human PI3Kgamma expressed in SF9 insect cells after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50308767(PKI-402 | 1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3...)
Affinity DataIC50: 2nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50308767(PKI-402 | 1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3...)
Affinity DataIC50: 3nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50308767(PKI-402 | 1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human P13Kalpha incubated for 2 hrs by fluorescent polarization methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed