BDBM50121710 2-(2,6-Diethyl-phenyl)-4H-isoquinoline-1,3-dione::CHEMBL88645::PIQ-22

SMILES CCc1cccc(CC)c1-n1c(O)cc2ccccc2c1=O

InChI Key InChIKey=CQTGQCXLVRVXLV-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50121710   

TargetPuromycin-sensitive aminopeptidase(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50121710(PIQ-22 | 2-(2,6-Diethyl-phenyl)-4H-isoquinoline-1,...)
Affinity DataIC50: 7.80E+3nMAssay Description:Puromycin sensitive aminopeptidase inhibitory activity by the use of L-Ala AMC with MOLT-4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50121710(PIQ-22 | 2-(2,6-Diethyl-phenyl)-4H-isoquinoline-1,...)
Affinity DataIC50: 3.40E+5nMAssay Description:Inhibitory activity against dipeptidyl peptidase IV (DPP- IV)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50121710(PIQ-22 | 2-(2,6-Diethyl-phenyl)-4H-isoquinoline-1,...)
Affinity DataIC50: 409nMAssay Description:Inhibitory activity against aminopeptidase N assayed by the L-Ala-MCA method.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50121710(PIQ-22 | 2-(2,6-Diethyl-phenyl)-4H-isoquinoline-1,...)
Affinity DataKi:  120nMAssay Description:Inhibition of APN (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed