BDBM50466806 PHA-680632

SMILES CCc1cccc(CC)c1NC(=O)N1Cc2[nH]nc(NC(=O)c3ccc(cc3)N3CCN(C)CC3)c2C1

InChI Key InChIKey=OBWNXGOQPLDDPS-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50466806   

TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50466806(PHA-680632)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAurora kinase C(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50466806(PHA-680632)
Affinity DataIC50: 120nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase B(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50466806(PHA-680632)
Affinity DataIC50: 135nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50466806(PHA-680632)
Affinity DataIC50: 27nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of California Davis Cancer Center

Curated by ChEMBL
LigandPNGBDBM50466806(PHA-680632)
Affinity DataIC50: 390nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase C(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50466806(PHA-680632)
Affinity DataIC50: 120nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase B(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50466806(PHA-680632)
Affinity DataIC50: 35nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50466806(PHA-680632)
Affinity DataIC50: 27nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLIM domain kinase 1/2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50466806(PHA-680632)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAurora kinase B(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50466806(PHA-680632)
Affinity DataIC50: 135nMAssay Description:Inhibition of GST-tagged recombinant human Aurora B kinase expressed in High5 cells using Auroratide substrate and [gamma33-ATP] by scintillation pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50466806(PHA-680632)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50466806(PHA-680632)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50466806(PHA-680632)
Affinity DataIC50: 575nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50466806(PHA-680632)
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50466806(PHA-680632)
Affinity DataIC50: 407nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAurora kinase C(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50466806(PHA-680632)
Affinity DataIC50: 120nMAssay Description:Inhibition of GST-tagged recombinant human Aurora C kinase expressed in High5 cells using Auroratide substrate and [gamma33-ATP] by scintillation pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50466806(PHA-680632)
Affinity DataIC50: 27nMAssay Description:Inhibition of GST-tagged recombinant human Aurora A kinase expressed in High5 cells using LRRWSLGL substrate and [gamma33-ATP] by scintillation proxi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed