BDBM188517 PF-CBP1

SMILES CCCOc1ccc(CCc2nc3cc(ccc3n2CCN2CCOCC2)-c2c(C)noc2C)cc1

InChI Key InChIKey=CGWBJJZOKGZCSJ-UHFFFAOYSA-N

Data  10 IC50  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 188517   

TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM188517(PF-CBP1)
Affinity DataIC50: 130nMAssay Description:The assay used His-tagged CBP protein, biotinylated histone H4, and detection reagents europium-labeled streptavidin and anti-6His antibody labeled w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandPNGBDBM188517(PF-CBP1)
Affinity DataIC50: 1.81E+4nMAssay Description:The assay used a Cy5 dye-labeled BRD inhibitor PFI-411FP. The synthesis of the probe and the procedure for the assay was reported recently (Hett et a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM188517(PF-CBP1)
Affinity DataKd:  190nMAssay Description:Experiments were performed using recombinant CBP and BRD4 bromodomainsusing the procedure reported recently (Hett et al., 2015).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandPNGBDBM188517(PF-CBP1)
Affinity DataKd: >2.00E+4nMAssay Description:Experiments were performed using recombinant CBP and BRD4 bromodomainsusing the procedure reported recently (Hett et al., 2015).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM188517(PF-CBP1)
Affinity DataIC50: 190nMAssay Description:Displacement of biotinylated ligand from CBP (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMed
LigandPNGBDBM188517(PF-CBP1)
Affinity DataEC50:  6.60E+3nMAssay Description:Inhibition of CBP/EP300 (unknown origin) assessed as reduction in MYC expression by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM188517(PF-CBP1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Halo-tagged histone H3.3 binding to NanoLuc luciferase conjugated CBP (unknown origin) expressed in HEK293 cells after overnight incuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMed
LigandPNGBDBM188517(PF-CBP1)
Affinity DataIC50: 2.90E+3nMAssay Description:Displacement of biotinylated ligand from BRD4 bromodomain-1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMed
LigandPNGBDBM188517(PF-CBP1)
Affinity DataIC50: 1.81E+4nMAssay Description:Inhibition of BRD4 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2019
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM188517(PF-CBP1)
Affinity DataIC50: 620nMAssay Description:Displacement of [3H]prazosin from recombinant human adrenergic A1a receptor after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2019
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM188517(PF-CBP1)
Affinity DataIC50: 130nMAssay Description:Inhibition of CREBBP (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2019
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Pfizer

LigandPNGBDBM188517(PF-CBP1)
Affinity DataIC50: 130nMAssay Description:Inhibition of CBP (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM188517(PF-CBP1)
Affinity DataIC50: 1.81E+4nMAssay Description:Binding affinity to BRD4 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed