BDBM50317209 (2R)-N-(adamantan-2-yl)-1-ethylpyrrolidine-2-carboxamide::CHEMBL1095047::PF-877423

SMILES CCN1CCC[C@@H]1C(=O)NC1C2CC3CC(C2)CC1C3

InChI Key

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50317209   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317209(PF-877423 | (2R)-N-(adamantan-2-yl)-1-ethylpyrroli...)
Affinity DataIC50: 4.15nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317209(PF-877423 | (2R)-N-(adamantan-2-yl)-1-ethylpyrroli...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of 11betaHSD1 expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317209(PF-877423 | (2R)-N-(adamantan-2-yl)-1-ethylpyrroli...)
Affinity DataIC50: 90nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes using [3H]cortisone as substrate preincubated for 15 mins followed by substrate addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2020
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317209(PF-877423 | (2R)-N-(adamantan-2-yl)-1-ethylpyrroli...)
Affinity DataIC50: 4nMAssay Description:Inhibition of 11beta-HSD1 in human liver microsomes assessed as conversion of [3H]-cortisone to [3H]-cortisol after 30 mins by scintillation proximit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317209(PF-877423 | (2R)-N-(adamantan-2-yl)-1-ethylpyrroli...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human 11-beta-HSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed