BDBM50507839 PF-6305591::Pf-06305591

SMILES C[C@H]([C@H](N)c1nc2ccc(cc2[nH]1)C(C)(C)C)C(N)=O

InChI Key InChIKey=APWZIFIAVVFPNT-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50507839   

LigandPNGBDBM50507839(PF-6305591 | Pf-06305591)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human Nav1.2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50507839(PF-6305591 | Pf-06305591)
Affinity DataIC50: 15nMAssay Description:Inhibition of Nav1.8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
LigandPNGBDBM50507839(PF-6305591 | Pf-06305591)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50507839(PF-6305591 | Pf-06305591)
Affinity DataIC50: 15nMAssay Description:Inhibition of human Nav1.8 expressed in HEK cells by patch-clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50507839(PF-6305591 | Pf-06305591)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human Nav1.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50507839(PF-6305591 | Pf-06305591)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human Nav1.7More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50507839(PF-6305591 | Pf-06305591)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of SK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50507839(PF-6305591 | Pf-06305591)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of L-type calcium channel (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50507839(PF-6305591 | Pf-06305591)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human Nav1.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50507839(PF-6305591 | Pf-06305591)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of GABA receptor alpha1gamma2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50507839(PF-6305591 | Pf-06305591)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50507839(PF-6305591 | Pf-06305591)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human Nav1.3More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50507839(PF-6305591 | Pf-06305591)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human Nav1.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50507839(PF-6305591 | Pf-06305591)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of KvLQT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50507839(PF-6305591 | Pf-06305591)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Kv1.1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50507839(PF-6305591 | Pf-06305591)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Kv1.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetVoltage-gated T-type calcium channel(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50507839(PF-6305591 | Pf-06305591)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of T-type calcium channel (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50507839(PF-6305591 | Pf-06305591)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human Nav1.6More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed