BDBM26741 N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carboxamide::PF-622::US9169224, 19

SMILES O=C(Nc1ccccc1)N1CCN(Cc2ccc3ccccc3n2)CC1

InChI Key InChIKey=SNTCRRMCALVGNL-UHFFFAOYSA-N

Data  12 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 26741   

TargetFatty-acid amide hydrolase 1(Human)
Pfizer

LigandPNGBDBM26741(N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...)
Affinity DataIC50: 991nMpH: 7.4 T: 2°CAssay Description:FAAH activity was measured by following the production of ammonia generated from the hydrolysis of oleamide by FAAH. GDH catalyzes the condensation o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2009
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Pfizer

LigandPNGBDBM26741(N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...)
Affinity DataIC50: 687nMpH: 7.4 T: 2°CAssay Description:FAAH activity was measured by following the production of ammonia generated from the hydrolysis of oleamide by FAAH. GDH catalyzes the condensation o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2009
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Pfizer

LigandPNGBDBM26741(N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...)
Affinity DataIC50: 473nMpH: 7.4 T: 2°CAssay Description:FAAH activity was measured by following the production of ammonia generated from the hydrolysis of oleamide by FAAH. GDH catalyzes the condensation o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2009
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Pfizer

LigandPNGBDBM26741(N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...)
Affinity DataIC50: 33nMpH: 7.4 T: 2°CAssay Description:FAAH activity was measured by following the production of ammonia generated from the hydrolysis of oleamide by FAAH. GDH catalyzes the condensation o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2009
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Pfizer

LigandPNGBDBM26741(N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...)
Affinity DataIC50: 19nMpH: 9.0Assay Description:Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2016
Entry Details
Go to US Patent

TargetFatty-acid amide hydrolase 1(Human)
Pfizer

LigandPNGBDBM26741(N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...)
Affinity DataIC50: 23nMpH: 9.0Assay Description:Assay Method 1: T84 frozen pellets (contents of 1-4x15 cm culture dishes) were homogenized in 300 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0....More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2016
Entry Details
Go to US Patent

TargetFatty-acid amide hydrolase 1(Human)
Pfizer

LigandPNGBDBM26741(N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...)
Affinity DataIC50: 350nMpH: 9.0Assay Description:T84 frozen cell pellets or transfected SK-N-MC cells (contents of 1x15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2016
Entry Details
Go to US Patent

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM26741(N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as decrease in intracellular calcium levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM26741(N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...)
Affinity DataEC50: >2.50E+4nMAssay Description:Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as decrease in intracellular calcium levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Pfizer

LigandPNGBDBM26741(N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...)
Affinity DataIC50: 33nMAssay Description:Inhibition of FAAHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM26741(N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...)
Affinity DataIC50: 500nMAssay Description:Inhibition of FAAH-mediated hydrolysis of [3H]AEA in rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Pfizer

LigandPNGBDBM26741(N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...)
Affinity DataIC50: 991nMAssay Description:Inhibition of recombinant human N-terminal -His6 tagged FAAH (32 to 579 residues) expressed in Escherichia coli BL21-AI preincubated for 5 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Pfizer

LigandPNGBDBM26741(N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carbo...)
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant human N-terminal -His6 tagged FAAH (32 to 579 residues) expressed in Escherichia coli BL21 preincubated for 60 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed