BDBM50318872 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(3-((pyridin-3-yloxy)methyl)-1H-pyrazol-5-yl)urea::CHEMBL1084269::PF-4618433

SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1cc(COc2cccnc2)n[nH]1)C(C)(C)C

InChI Key InChIKey=NJARPUHZDSAXPL-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50318872   

TargetProtein-tyrosine kinase 2-beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50318872(1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(3-((...)
Affinity DataIC50: 637nMAssay Description:Inhibition of PYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50318872(1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(3-((...)
Affinity DataIC50: 637nMAssay Description:Inhibition of human recombinant C-terminal His-tagged PYK2 using ATP as substrate incubated for 1 hr prior to substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318872(1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(3-((...)
Affinity DataIC50: 190nMAssay Description:Inhibition of PYK2 in mouse NIH-3T3 cells by LI-COR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318872(1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(3-((...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FAK after 2hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50318872(1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(3-((...)
Affinity DataIC50: 637nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed