BDBM50297077 (S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(trifluoromethyl)benzamide::CHEMBL552338::PF-3409409

SMILES FC(F)(F)c1ccccc1C(=O)N(CC1CCC1)[C@H]1CCNC1

InChI Key InChIKey=SWADTMSKMJUFBO-UHFFFAOYSA-N

Data  6 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50297077   

TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataIC50: 1.51E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of CYP3A4 using felodipine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataIC50: 1.22E+4nMAssay Description:Inhibition of CYP3A4 using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataIC50: 3.12E+4nMAssay Description:Inhibition of CYP3A4 using testosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataIC50: 2.60E+4nMAssay Description:Blockade of Nav1.5 sodium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetTransporter(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to rat NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]nisoxetine from human recombinant NET expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataKi:  224nMAssay Description:Displacement of [3H]citalopram from human recombinant SERT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataKi:  1.80E+3nMAssay Description:Binding affinity to human muscarinic M5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataKi:  2.29E+3nMAssay Description:Displacement of radioligand from human recombinant DAT expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50297077((S)-N-(cyclobutylmethyl)-N-(pyrrolidin-3-yl)-2-(tr...)
Affinity DataKi:  4.30E+3nMAssay Description:Binding affinity to human muscarinic M4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed